ACCase-inhibiting herbicides: mechanism of action, resistance evolution and stewardship

Takano, Hudson Kagueyama; Ovejero, R. F. Lopez; Belchior, Gustavo Gross; Maymone, Gizella Potrich Leal; Dayan, Franck E.

doi:10.1590/1678-992x-2019-0102

Cited by 62 publications

(72 citation statements)

References 77 publications

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“…Resistance to different chemical classes of ACCase-inhibiting herbicide in L. rigidum can result from TSR, or/and NTSR mechanisms ( Takano et al, 2021 ). Point mutations at Trp-2027 and Asp-2078 in the ACCases of the two HR populations ESR-1 and ESR-2 were determined, with no TSR-conferring mutations found at any of the four positions tested in the HR population ES-resistant 3.…”

Section: Discussionmentioning

confidence: 99%

Target-Site and Non-target-Site Resistance Mechanisms Confer Multiple and Cross- Resistance to ALS and ACCase Inhibiting Herbicides in Lolium rigidum From Spain

et al. 2021

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Lolium rigidum is one the worst herbicide resistant (HR) weeds worldwide due to its proneness to evolve multiple and cross resistance to several sites of action (SoA). In winter cereals crops in Spain, resistance to acetolactate synthase (ALS)- and acetyl-CoA carboxylase (ACCase)-inhibiting herbicides has become widespread, with farmers having to rely on pre-emergence herbicides over the last two decades to maintain weed control. Recently, lack of control with very long-chain fatty acid synthesis (VLCFAS)-inhibiting herbicides has been reported in HR populations that are difficult to manage by chemical means. In this study, three Spanish populations of L. rigidum from winter cereals were confirmed as being resistant to ALS- and ACCase-inhibiting herbicides, with broad-ranging resistance toward the different chemistries tested. In addition, reduced sensitivity to photosystem II-, VLCFAS-, and phytoene desaturase-inhibiting herbicides were confirmed across the three populations. Resistance to ACCase-inhibiting herbicides was associated with point mutations in positions Trp-2027 and Asp-2078 of the enzyme conferring target site resistance (TSR), while none were detected in the ALS enzyme. Additionally, HR populations contained enhanced amounts of an ortholog of the glutathione transferase phi (F) class 1 (GSTF1) protein, a functional biomarker of non-target-site resistance (NTSR), as confirmed by enzyme-linked immunosorbent assays. Further evidence of NTSR was obtained in dose-response experiments with prosulfocarb applied post-emergence, following pre-treatment with the cytochrome P450 monooxygenase inhibitor malathion, which partially reversed resistance. This study confirms the evolution of multiple and cross resistance to ALS- and ACCase inhibiting herbicides in L. rigidum from Spain by mechanisms consistent with the presence of both TSR and NTSR. Moreover, the results suggest that NTSR, probably by means of enhanced metabolism involving more than one detoxifying enzyme family, confers cross resistance to other SoA. The study further demonstrates the urgent need to monitor and prevent the further evolution of herbicide resistance in L. rigidum in Mediterranean areas.

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Section: Discussionmentioning

confidence: 99%

Target-Site and Non-target-Site Resistance Mechanisms Confer Multiple and Cross- Resistance to ALS and ACCase Inhibiting Herbicides in Lolium rigidum From Spain

et al. 2021

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“…Furthermore, glufosinate is not considered volatile and the newer transgenic technologies for herbicide‐resistant crops tend to stack multiple events, including glufosinate resistance as one of their traits in most varieties. Glufosinate will also continue playing an important role in tropical countries such as Brazil, where grasses are the biggest challenge for weed management 12 and paraquat has recently been banned. Lastly, while there has been an increased effort to develop new herbicide modes of action, no new effective and non‐selective herbicide is expected to launch in the next few years 13 …”

Section: Discovery and Commercializationmentioning

confidence: 99%

Glufosinate‐ammonium: a review of the current state of knowledge

Takano

Dayan

2020

Pest Management Science

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Glufosinate is a key herbicide to manage glyphosate-resistant weeds mainly because it is a broad-spectrum herbicide, and transgenic glufosinate-resistant crops are available. Although glufosinate use has increased exponentially over the past decade, the treated area with this herbicide is far less than that with glyphosate. This is because glufosinate often provides inconsistent performance in the field, which is attributed to several factors including environmental conditions, application technology, and weed species. Glufosinate is also highly hydrophilic and does not translocate well in plants, generally providing poor control of grasses and perennial species. In the soil, glufosinate is rapidly degraded by microorganisms, leaving no residual activity. While there have been concerns regarding glufosinate toxicology, its proper use can be considered safe. Glufosinate is a fast-acting herbicide that was first discovered as a natural product, and is the only herbicide presently targeting glutamine synthetase. The mode of action of glufosinate has been controversial, and the causes for the rapid phytotoxicity have often been attributed to ammonia accumulation. Recent studies indicate that the contact activity of glufosinate results from the accumulation of reactive oxygen species and subsequent lipid peroxidation. Glufosinate disrupts both photorespiration and the light reactions of photosynthesis, leading to photoreduction of molecular oxygen, which generates reactive oxygen species. The new understanding of the mode of action provided new ideas to improve the herbicidal activity of glufosinate. Finally, a very few weed species have evolved glufosinate resistance in the field, and the resistance mechanisms are generally not well understood requiring further investigation.

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“…The main foliar-applied herbicide used in chemical weed management of tough lovegrass is glyphosate (HEAP & DUKE, 2018), that inhibits the 5-enolpyruvyl-shikimate-3-phosphate synthase enzyme -EPSPs. However, with the evolution of resistance to herbicides, another modes of action as acetolactate synthase (ALS) (YU & POWLES, 2014) and acetyl-coenzyme A carboxylase (ACCase) inhibiting herbicides (TAKANO et al, 2020) are needed to be evaluated as alternative options to glyphosate. Glyphosate has broad-spectrum of action and ALS inhibiting herbicides have action on monocotyledons and/or dicotyledons plants according to the molecule (HEAP & DUKE, 2018;YU & POWLES, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Glyphosate has broad-spectrum of action and ALS inhibiting herbicides have action on monocotyledons and/or dicotyledons plants according to the molecule (HEAP & DUKE, 2018;YU & POWLES, 2014). ACCase inhibiting herbicides are specific to grass weed control (TAKANO et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Integrated management of tough lovegrass (Eragrostis plana Nees): associating chemical control tools and plant physiology

et al. 2021

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The objective of the study was to evaluate the efficiency of herbicides use in the control of tough lovegrass according to the availability of solar radiation and the presence or absence of flooded. Two experiments were conducted in a completely randomized design, in a 2x2x4 and 2x2x5 factorial scheme, where factor A was equivalent to the environment (natural or reduced radiation); factor B to water condition (with a 2 cm flooded or without); and, factor C the herbicides: cyhalofop butyl (315 g ha-1), glyphosate (1080 g ha-1), cyhalofop butyl + glyphosate (315 g ha-1 + 1080 g ha-1) and control (without application) in the first experiment. In the second experiment, the herbicides used were cyhalofop butyl (315 g ha-1), glyphosate (1080 g ha-1), sethoxydim (184g ha-1), imazethapyr (106 g ha-1) and control (without application). Glyphosate efficiently controls plants of tough lovegrass with four tillers (>90%), being superior to cyhalofop, imazethapyr and sethoxydim; independently, of resource conditions. Reduction in the availability of solar radiation generates less shoot dry mass production from the weed, and improves the control only by imazethapyr and cyhalofop. In general, a flooded condition does not affect tough lovegrass control by herbicides.

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ACCase-inhibiting herbicides: mechanism of action, resistance evolution and stewardship

Cited by 62 publications

References 77 publications

Target-Site and Non-target-Site Resistance Mechanisms Confer Multiple and Cross- Resistance to ALS and ACCase Inhibiting Herbicides in Lolium rigidum From Spain

Target-Site and Non-target-Site Resistance Mechanisms Confer Multiple and Cross- Resistance to ALS and ACCase Inhibiting Herbicides in Lolium rigidum From Spain

Glufosinate‐ammonium: a review of the current state of knowledge

Integrated management of tough lovegrass (Eragrostis plana Nees): associating chemical control tools and plant physiology

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