Acaricidal activity against <i>Panonychus citri</i> of a ginkgolic acid from the external seed coat of <i>Ginkgo biloba</i>

Pan, Weiyi; Luo, Peng; Fu, Ruobin; Gao, Ping; Long, Zhijian; Xu, Feiyi; Xiao, Haibo; Liu, Shigui

doi:10.1002/ps.1152

Cited by 31 publications

(20 citation statements)

References 20 publications

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“…It was also shown that 6-[(Z)-10-heptadecenyl]-2-hydroxybenzoic acid from the external seed coat of G. biloba has an acaricidal activity against Panonychus citri. The contact toxicity of this compound was similar or significantly superior to those of pyridaben and omethoate, systemic insecticidal and acaricidal compounds [168]. Phenolic lipids also exhibit larvicidal activity.…”

Section: Phenolic Lipids Inhibit Bacterial Fungal Protozoan and Pamentioning

confidence: 77%

Biological activity of phenolic lipids

Stasiuk

Kozubek

2009

Cell. Mol. Life Sci.

228

158

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Phenolic lipids are a very diversified group of compounds derived from mono and dihydroxyphenols, i.e., phenol, catechol, resorcinol, and hydroquinone. Due to their strong amphiphilic character, these compounds can incorporate into erythrocytes and liposomal membranes. In this review, the antioxidant, antigenotoxic, and cytostatic activities of resorcinolic and other phenolic lipids are described. The ability of these compounds to inhibit bacterial, fungal, protozoan and parasite growth seems to depend on their interaction with proteins and/or on their membrane-disturbing properties.

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Section: Phenolic Lipids Inhibit Bacterial Fungal Protozoan and Pamentioning

confidence: 77%

Biological activity of phenolic lipids

Stasiuk

Kozubek

2009

Cell. Mol. Life Sci.

228

158

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“…In Xingasn (Guangxi Province, PR China), fruit juice produced during the peeling process was diluted with water and used as an insecticide by local peasants. Satisfactory results were achieved in the control of many kinds of insects [3,5,6] .…”

Section: Introductionmentioning

confidence: 92%

“…As a result of this disposal, the soil and water became polluted, poisoning the organisms living within. However, the seed coat also contains many useful constituents [3,4] . In Xingasn (Guangxi Province, PR China), fruit juice produced during the peeling process was diluted with water and used as an insecticide by local peasants.…”

Section: Introductionmentioning

confidence: 99%

Antitumor Effects of Ginkgolic Acid in Human Cancer Cell Occur via Cell Cycle Arrest and Decrease the Bcl-2/Bax Ratio to Induce Apoptosis

Zhou¹,

Li²,

Du³

et al. 2010

Chemotherapy

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Background: Ginkgolic acids (GAs), extracted from the seed coat of Ginkgo biloba L. Our previous study has shown that GA monomer could inhibit the growth of Hep-2 significantly and induce the fragmentation of the chromosomal DNA. To further assess the antitumor potential and turn it into a candidate new antitumor drug, the antitumor mechanism of GA was investigated. Method: The cytotoxicity and antitumor effect of GA monomer were assayed by MTT colorimetric assay with nontumorogenic MC-3T3-E1 as well as tumorogenic Hep-2 and Tac8113 cell lines. The effect of GA monomer on the proliferation of tumor cell lines was analyzed with MTT colorimetric and CFSE labeled assay. Cell cycle distribution and measurement of the percentage of apoptotic cells were performed by flow cytometry following stained with propidium iodide, annexin V-FITC. The expression of apoptotic proteins Bcl-2, Bax and caspase-3 was analyzed with Western blot. Result: GA only inhibited the growth of tumorogenic cell lines in a both dose- and time-dependent manner. Tumor cells were treated with GA for 72 h, 70.53 ± 4.54% Hep-2 and 63.5 ± 7.2% Tca8113 cells were retarded at GO/G1 phase, and the percentage of apoptosis was 40.4 ± 1.58 and 38.4 ± 1.7%, respectively. GA-treated activated caspase-3 downregulated the expression of anti-apoptotic Bcl-2 protein and upregulated the expression of pro-apoptotic Bax protein, eventually leading to a decrease in the Bcl-2/Bax ratio in tumor cells. Conclusions: The antitumor action of GA was due to inhibiting the proliferation in a manner of inhibiting division, retarding the progress of cell cycle and inducing apoptosis, making GA a candidate as new antitumor drug.

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“…Another study evaluated the acaricidal activity against this mite of a ginkgolic acid, 6-[(Z)-10heptadecenyl]-2-hydroxybenzoic acid, isolated from the external seed coat of Ginkgo biloba [54]. Laboratory bioassays showed that this compound possessed powerful contact toxicity, similar to that of pyridaben and significantly superior to that of omethoate.…”

Section: Agriculturementioning

confidence: 99%

Acaricides of Natural Origin. Part 2. Review of the Literature (2002–2006)

Flamini¹

2006

Natural Product Communications

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Dedicated to the memory of Professor Ivano Morelli.Acari are responsible for millions of dollars worth of damage each year as a result of infestations of animals, plants and man. They directly affect our health and prosperity as animal and plant parasites, vectors of disease, and producers of allergens. The indiscriminate use of pesticides has quickly induced resistance in many parasites. At present, the control of acarid parasitic diseases in agriculture, human and veterinary medicine is mainly based on the use of drugs; and for this reason the lack of effective drugs often prevents the control of some parasitic diseases, making them more serious and important. The use of commercial drugs involves many problems, besides the drug-resistance shown by the most important parasites. Environmental damage and the toxicity of many synthetic drugs, represent the main problems that strongly limit drug use. In addition, drug residues in plant and animal food products are important reasons for further economic losses for farmers and must be regarded as potentially hazardous to man and the environment. Plant-derived compounds are generally more easily degradable and could show a smaller negative environmental impact with respect to synthetic drugs. For these reasons, the evaluation of the antiacarid activity of plant extracts is increasingly being investigated in order to obtain new leads, as demonstrated by recent studies that have evaluated and confirmed the effectiveness of many plant compounds on bacteria, fungi, protozoa, helminths and arthropods. This review will be limited to the class Arachnida, sub-class Acaridi, particularly to their control in agriculture, veterinary and human medicine using natural methods.

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Acaricidal activity against Panonychus citri of a ginkgolic acid from the external seed coat of Ginkgo biloba

Cited by 31 publications

References 20 publications

Biological activity of phenolic lipids

Biological activity of phenolic lipids

Antitumor Effects of Ginkgolic Acid in Human Cancer Cell Occur via Cell Cycle Arrest and Decrease the Bcl-2/Bax Ratio to Induce Apoptosis

Acaricides of Natural Origin. Part 2. Review of the Literature (2002–2006)

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