Acanthospermum hispidum DC (Asteraceae): perspectives for a phytotherapeutic product

Araújo, Evani de Lemos; Randau, Karina Perrelli; Sena-Filho, José G.; Pimentel, Rejane Magalhães de Mendonça; Xavier, Haroudo Sátiro

doi:10.1590/s0102-695x2008000500024

Cited by 20 publications

(10 citation statements)

References 30 publications

(34 reference statements)

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“…However, the Dd2 strain was not used. Aerial parts of Acanthospermum hispidum have been shown to contain antioxidants, glycosides, coumarins and flavonoids (Araùjo et al 2008). Thereby, the antiplasmodial activity observed in this study might be attributed to one of these compounds since antioxidants, glycosides, coumarins and flavonoids have been reported to possess antimalarial activity (Sriwilaijroen et al, 2010).…”

Section: Discussionsupporting

confidence: 48%

In vitro evaluation of antiplasmodial activity of extracts of Acanthospermum hispidum dc (Asteraceae) and Ficus thonningii blume (moraceae), two plants used in traditional medicine in the republic of Congo

Koukouikila-Koussounda¹,

Abena²,

Nzoungani³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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The aim of this study was to evaluate extracts from two medicinal plants, Acanthospermum hispidum and Ficus thonningii, used in traditional medicine in Congo Brazzaville, for in vitro antiplasmodial activities against two laboratory strains of Plasmodium falciparum: the chloroquine sensitive 3D7 and the chloroquine resistant Dd2. ELISA HRP2 assay was used to evaluate the in vitro inhibitory activity of the extracts alone or in combination with chloroquine. Cytotoxicity was assessed on human HeLa cell line and reflected by the selectivity index. Methanolic extract of Acanthospermum hispidum exhibited a strong and a moderate inhibitory activity on the growth of Dd2 and 3D7 at 2.8 µg/ml and 9.2 µg/ml concentrations respectively with a selectivity index >10. The combination of the most active extract (methanolic extract of Acanthospermum hispidum) with chloroquine showed a synergistic interaction on both strains. The good selectivity index of Acanthospermum hispidum on HeLa cells reflects the safety of this plant. Extracts from Ficus thonningii did not show any promising antiplasmodial activity on both 3D7 and Dd2. Except the methanolic extract which exhibited a slight antiplasmodial activity with inhibitory concentration and selectivity index corresponding to 9.61 µg/ml and 11.16 respectively. Methanolic extract of Acanthospermum hispidum exhibited moderate to high inhibitory activity on 3D7 and Dd2 laboratory strains and a synergistic antimalarial effect when combined with chloroquine. Ficus thonningii seems to have no antimalarial activity. Phytochemical analysis, in vivo investigations using animal models and later clinical trials in collaboration with traditional practitioners are necessary to clarify the potential antimalarial activity of both plants.

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Section: Discussionsupporting

confidence: 48%

In vitro evaluation of antiplasmodial activity of extracts of Acanthospermum hispidum dc (Asteraceae) and Ficus thonningii blume (moraceae), two plants used in traditional medicine in the republic of Congo

Koukouikila-Koussounda¹,

Abena²,

Nzoungani³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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“…Acanthospermum hispidum was the subject of several previous studies which showed many biological activities (Araújo et al, 2008). If in vitro antiplasmodial activity was already described with extracts of the plant, and was shown to be higher for a specific extract defined as "alkaloid" extract (Sanon et al, 2003;Bero et al, 2009), it is the first time that sesquiterpenic lactones are clearly related to the activity of this plant.…”

Section: In Vitro Antiplasmodial and Cytotoxic Activitiesmentioning

confidence: 99%

Antiparasitic activities of two sesquiterpenic lactones isolated from Acanthospermum hispidum D.C.

Ganfon

Béro

Tchinda

et al. 2012

Journal of Ethnopharmacology

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“…Asteraceae é bastante estudada, também devido aos promissores compostos químicos produzidos por este grupo (ARAUJO et al 2008). Bahia (1979) já citava o alumã (Vernonia bahiensis Tol.)…”

Section: Continuaçãounclassified

Estudo Etnobotânico de plantas medicinais utilizadas pela Comunidade do Sisal no município de Catu, Bahia, Brasil

Neto

Almeida

Jesus

et al. 2014

Rev. bras. plantas med.

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RESUMO:A utilização de plantas medicinais é instintiva nos animais, visto que alguns destes buscam raízes, cascas, folhas ou frutos na tentativa de resolver seus males. O homem, por sua vez, aprendeu a utilizar estas informações empiricamente para fazer uso destes vegetais. A medicina popular é uma importante alternativa, provavelmente, a mais usada para a cura de doenças por parte de populações indígenas, quilombolas ou rurais. A Etnobotânica, por sua vez, encarrega-se de estudar e interpretar essa relação dos homens com o mundo vegetal. Devido ao seu grande potencial biológico e cultural, o Brasil apresenta uma infinidade de conhecimentos tradicionais e espécies vegetais importantes, o que torna esse país uma grande fonte de pesquisa na área. Visando avaliar o conhecimento tradicional da população rural do Sisal, Catu/Bahia, relacionado ao uso de plantas medicinais, este trabalho iniciou-se em julho de 2009, constando de entrevistas semi-estruturadas e estruturadas, gravações, registros fotográficos, coleta do material botânico indicado nas entrevistas com os informantes, tratamento do material coletado e incorporação ao Herbário da Universidade do Estado da Bahia (HUNEB).Foram identificadas e coletadas 54 espécies distribuídas em 46 gêneros e 28 famílias, sendo Lamiacaeae e Asteraceae as mais representativas. A maioria das plantas é constituída de ervas e cultivada nos quintais dos moradores. O estudo revelou que a comunidade apresenta uma medicina popular bastante rica, com grande diversidade de espécies vegetais e usos por parte da população.Palavras-chave: Etnobotânica, conhecimento tradicional, plantas medicinais, medicina popular.ABSTRACT: Ethnobotanical study of medicinal plants used by the Sisal Community in the city of Catu, Bahia, Brazil. The use of medicinal plants is instinctive in animals, since some of these seek roots, bark, leaves or fruits in an attempt to cure their diseases. Man, in turn, learned to use this information on the use of these plants empirically. Folk medicine is an important alternative, probably the most used to cure diseases by indigenous peoples, Afro-descendants and rural populations. Ethnobotany, in turn, undertakes to study and interpret the relationship of men with the plant world. Because of its great biological and cultural potential, Brazil has a wealth of traditional knowledge and important plant species, what makes this country a great source of research in the area. To evaluate the traditional knowledge of the rural population of Sisal, city of Catu, state of Bahia, Brazil, related to use of medicinal plants, this work began in July 2009, consisting of semi-structured and structured interviews, recordings, photographs, collection of botanical material indicated in the interviews with informants, treatment of the collected material and incorporation into the Herbarium of the University of Bahia (HUNEB). We identified and collected 54 species in 46 genera and 28 families, being Asteraceae and Lamiacaeae the most representative. Most plants are herbs grown in the back...

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Acanthospermum hispidum DC (Asteraceae): perspectives for a phytotherapeutic product

Cited by 20 publications

References 30 publications

<i>In vitro</i> evaluation of antiplasmodial activity of extracts of <i>Acanthospermum hispidum</i> dc (Asteraceae) and <i>Ficus thonningii</i> blume (moraceae), two plants used in traditional medicine in the republic of Congo

<i>In vitro</i> evaluation of antiplasmodial activity of extracts of <i>Acanthospermum hispidum</i> dc (Asteraceae) and <i>Ficus thonningii</i> blume (moraceae), two plants used in traditional medicine in the republic of Congo

Antiparasitic activities of two sesquiterpenic lactones isolated from Acanthospermum hispidum D.C.

Estudo Etnobotânico de plantas medicinais utilizadas pela Comunidade do Sisal no município de Catu, Bahia, Brasil

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