Acanthosis Nigricans with Endometrial Carcinoma: Case Report and Review of the Literature

Mekhail, Tarek; Markman, Maurie

doi:10.1006/gyno.2001.6472

Cited by 31 publications

(22 citation statements)

References 17 publications

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“…Among the neoplastic associations with pan, abdominal carcinomas are the most frequent (the preponderance being gastric adenocarcinomas 2,9,10 ), although a broad spectrum of cancers have been documented, including (but not limited to) neoplasia of the urinary bladder 11 , esophagus 12 , adrenals 13 , lung 5 , liver 14 , gall bladder 15 , ovaries 7 , and endometrium 6,16 . In the context of breast carcinoma, pan is rare 10 .…”

Section: Discussionmentioning

confidence: 99%

Occult Cause of Paraneoplastic Acanthosis Nigricans in a Patient with Known Breast Dcis: Case and Review

Jakubovic¹,

Sawires

Adam

2012

Current Oncology

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bilaterally [ Figure 1(A-B)], the perineum (Figure 2), and neck, although no lymphadenopathy was evident. The features of this exanthem were consistent with a diagnosis of acanthosis nigricans.Given the patient's absence of metabolic risk factors and the rapidity of onset of the cutaneous findings, paraneoplastic acanthosis nigricans (pan) was considered. To our knowledge, pan is most often associated with gastrointestinal tract malignancies and has not been reported in the setting of a ductal carcinoma in situ. Investigations were therefore undertaken to rule out a second occult malignancy that might be a better explanation for the findings.Chest computed tomography (ct) imaging, esophagogastroduodenoscopy, and colonoscopy were all normal, but carbohydrate antigen 19-9 (a tumour marker for pancreatic adenocarcinoma and colorectal cancer) was elevated at 209 kU/L. Abdominal ct revealed a large dilated cystic structure in the gallbladder fossa in which lobulated soft tissue was noted; large masses in the pancreatic bed and porta hepatis were also observed. Marked retroperitoneal adenopathy consistent with metastatic cancer was also noted in the para-aortic region bilaterally.A ct-g uided biopsy of the retroperitoneal lymph nodes demonstrated carcinoma of an undetermined primary. On staining, tumour cells were positive for epithelial membrane antigen and carcinoembryonic antigen, but negative for cytokeratins 7 and 20, estrogen receptor, thyroid transcription factor 1, and calretinin. This staining pattern pointed toward tumours of biliary, pancreatic, and gastric origin, and was not consistent with metastatic breast cancer.The local Tumour Board reviewed the patient's case and concluded that the intra-abdominal findings were most consistent with metastatic cholangiocarcinoma arising from the choledochal cyst. The patient was deemed to have non-curable disease and was offered treatment with palliative chemotherapy. ABSTRACTParaneoplastic acanthosis nigricans (pan) is an infrequently encountered cutaneous manifestation of internal malignancy. Here, we describe a case of pan in the setting of a known breast ductal carcinoma in situ, which, to our knowledge, had not been described in association with pan. As a result, thorough investigation was undertaken to search for another concurrent neoplasm that would better explain the development of pan. In so doing, we identified a coexisting metastatic cholangiocarcinoma. We thus conclude that when pan is observed in an uncommon association with a known malignancy, further investigation should be undertaken to explore whether a more likely occult culprit exists. KEY WORDSAcanthosis nigricans, paraneoplastic acanthosis nigricans, cholangiocarcinoma, ductal carcinoma in situ CASE DESCRIPTIONA 51-year-old woman was seen in consultation in the dermatology clinic for progressive pruritic skin changes affecting the axilla, groin, and neck. She had been referred by her oncologist, who was managing her recently diagnosed breast cancer. Definitive treatment had been initiated and co...

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Section: Discussionmentioning

confidence: 99%

Occult Cause of Paraneoplastic Acanthosis Nigricans in a Patient with Known Breast Dcis: Case and Review

Jakubovic¹,

Sawires

Adam

2012

Current Oncology

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“…La premiè re description de l'acanthosis nigricans maligne a é té faite par Pollitzer [11] et Janovsky [4] en 1890. Il s'agit d'une é ruption hyperpigmenté e inté ressant la ré gion axillaire, la nuque, les plis inguinaux, la ré gion poplité e et l'abdomen [9].…”

Section: Discussionunclassified

“…Tout l'inté rê t de l'acanthosis nigricans est basé sur l'association avec une pathologie maligne, en raison du fait qu'il s'agit d'une association dramatique pour le patient, puisque l'apparition d'une Hyperké ratose associé e à une papillomatose et acanthose modé ré e en plus d'un infiltrat inflammatoire lymphocytaire pé rivasculaire C A S C L I N I Q U E / C A S E R E P O R T S9 telle lé sion cutané e parané oplasique est associé e à une é volution rapidement fatale de la pathologie cancé reuse [6,9]. Il s'agit d'une manifestation cutané e parané oplasique qui donne le signal d'alarme de la pré sence d'un processus malin interne [3].…”

Section: Discussionunclassified

“…Le type histologique le plus fré quemment retrouvé est l'adé nocarcinome. Né anmoins, plusieurs auteurs ont rapporté d'autres types histologiques tels des sarcomes, des schwanomes, des leucé mies, des cancers à cellules transitionnelles du rein, des tumeurs de Wilms [9]. Le cancer de la vessie reste l'une des entité s les plus rares de cette association [13].…”

Section: Discussionunclassified

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Acanthosis nigricans, manifestation cutanée rare d’un carcinome urothélial de vessie: à propos d’un cas

Tazi

Mellas

et al. 2009

Oncologie

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“…Papillomatous changes may be noted in the oral cavity, and hyperkeratosis in a wrinkled or ridged pattern may develop on the palms (tripe palms; see below) and the dorsal surfaces of large joints. 65,66 The cutaneous changes can occur before, coincident with, or after the discovery of an underlying malignancy, which most often is an adenocarcinoma of the stomach. Tumors may be found in other organs within the abdominal cavity as well, with more than 95% being adenocarcinomas.…”

Section: Acanthosis Nigricansmentioning

confidence: 99%

Cutaneous Manifestations of Internal Malignancy

Thiers¹,

Sahn²,

Callen³

2009

CA: A Cancer Journal for Clinicians

126

107

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The skin often mirrors changes in the organism it envelops. Many neoplastic diseases that affect internal organs display cutaneous manifestations, which may be the presenting signs and symptoms of the underlying malignancy. These may reflect direct involvement of the skin by the tumor (ie, tumor metastasis) or indirect involvement, in which changes in the skin occur in the absence of malignant cells. This review focuses on the latter conditions, which are often referred to as paraneoplastic dermatoses. Included in the discussion are the cutaneous manifestations of inherited syndromes that are associated with an increased risk of internal malignancy, cutaneous changes in patients with hormone-secreting tumors, and the wide spectrum of proliferative and inflammatory dermatoses that have been associated with internal cancer. CA Cancer J Clin 2009;59:73-98.

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Acanthosis Nigricans with Endometrial Carcinoma: Case Report and Review of the Literature

Cited by 31 publications

References 17 publications

Occult Cause of Paraneoplastic Acanthosis Nigricans in a Patient with Known Breast Dcis: Case and Review

Occult Cause of Paraneoplastic Acanthosis Nigricans in a Patient with Known Breast Dcis: Case and Review

Acanthosis nigricans, manifestation cutanée rare d’un carcinome urothélial de vessie: à propos d’un cas

Cutaneous Manifestations of Internal Malignancy

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