Acanthosis Nigricans of the Forehead and Fingers Associated With Hyperinsulinemia

Hisler, Barbara M.; Savoy, L. Boyd

doi:10.1001/archderm.1987.01660350035013

Arch Dermatol

1987

DOI: 10.1001/archderm.1987.01660350035013

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Acanthosis Nigricans of the Forehead and Fingers Associated With Hyperinsulinemia

Barbara M. Hisler

L. Boyd Savoy²

Abstract: School for his cooperation in the measurement of lower esophage¬ al sphincter pressure.

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Cited by 4 publications

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“…This form of AN classically has a flexural distribution, affecting the axillae, groin, neck and submammary region. There is only one previous case report of AN associated with obesity and hyperinsulinaemia appearing on the face, in that case it was on the forehead 3 . Facial AN has also been reported in a boy, with a normal BMI, and no endocrine abnormalities, it was localized to the sulcus alaris nasi and sulcus mentolabialis.…”

mentioning

confidence: 92%

Facial acanthosis nigricans associated with obesity

Veysey

Ratnavel

2005

Clin Exp Dermatol

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mentioning

confidence: 92%

Facial acanthosis nigricans associated with obesity

Veysey

Ratnavel

2005

Clin Exp Dermatol

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Acanthosis nigricans

Schwartz¹

1994

Journal of the American Academy of Dermatology

289

261

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Acanthosis nigricans is a mucocutaneous eruption that occurs in a strikingly exuberant form as a marker for a highly malignant and rapidly fatal internal cancer. Recently, it has been recognized that acanthosis nigricans may also be a relatively common marker for increased long-term risk of the less dramatic but potentially serious systemic disorders associated with insulin resistance and compensatory increased insulin secretion.

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Clinical Features, Investigative Profile and Association with Metabolic Syndrome in Facial Acanthosis Nigricans: A Case–Control Study in Indian Patients

Rao,

Gopal,

Chennamsetty

et al. 2024

IJPGD

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Objectives: The present study was undertaken to study the clinical profile and laboratory abnormalities in patients with facial acanthosis nigricans (FANs). The significance of FAN as a marker of insulin resistance (IR), metabolic syndrome (MS) and its components was determined by comparing with controls without FAN. Materials and Methods: Fifty clinically diagnosed cases of FAN of all ages and both sexes were enrolled. Age- and sex-matched obese patients without FAN were included as controls. Waist circumference, blood pressure and body mass index were measured. Venous samples were taken from all patients and controls for measuring fasting glucose level, fasting insulin levels and fasting lipid profile. Statistical analysis was done using the Chi-square test and unpaired t-test. Results: The prevalence of hypertension, dysglycaemia, hyperlipidaemia, elevated Homeostatic Model Assessment for IR (HOMA-IR) and MS was significantly higher in cases of FAN than controls (P < 0.05). The mean levels of fasting blood sugar, HOMA-IR, hypertension, high-density lipoprotein and serum triglycerides were significantly higher in patients of FAN than controls (P < 0.05). The odds ratio for FAN cases developing MS was determined to be 5.31. Conclusion: FAN may be considered as a significant clinical marker of IR with increased risk for MS and its component when compared to controls. All patients with FAN should be considered for a thorough biochemical workup to rule out MS. In all detected cases, it is prudent to initiate prompt remedial measures including lifestyle changes and pharmacotherapy to prevent long-term morbidity and mortality.

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Acanthosis Nigricans of the Forehead and Fingers Associated With Hyperinsulinemia

Abstract: School for his cooperation in the measurement of lower esophage¬ al sphincter pressure.

Cited by 4 publications

References 7 publications

Facial acanthosis nigricans associated with obesity

Facial acanthosis nigricans associated with obesity

Acanthosis nigricans

Clinical Features, Investigative Profile and Association with Metabolic Syndrome in Facial Acanthosis Nigricans: A Case–Control Study in Indian Patients

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