Acanthopanacis Cortex extract: A novel photosensitizer for head and neck squamous cell carcinoma therapy

Shi, Shuhan; Cho, Hyejoung; Sun, Qiaochu; He, Yingkun; Ma, Guowu; Kim, Young; Kim, Byung-Gook; Kim, Ok-Su

doi:10.1016/j.pdpdt.2019.02.020

Cited by 9 publications

(4 citation statements)

References 36 publications

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“…Nevertheless, the search for new photosensitizers is also an active target for the development of PDT. Several works have reported the use of new compounds as promising photosensitizers [ 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 ]. From synthesized compounds based on previous structures to entirely new compounds, the research is in continuously update.…”

Section: Photodynamic Therapymentioning

confidence: 99%

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Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Oliveira

Correia

Pereira

et al. 2020

IJMS

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Due to their physical and chemical characteristics, anthocyanins are amongst the most versatile groups of natural compounds. Such unique signature makes these compounds a focus in several different areas of research. Anthocyanins have well been reported as bioactive compounds in a myriad of health disorders such as cardiovascular diseases, cancer, and obesity, among others, due to their anti-inflammatory, antioxidant, anti-diabetic, anti-bacterial, and anti-proliferative capacities. Such a vast number of action mechanisms may be also due to the number of structurally different anthocyanins plus their related derivatives. In this review, we highlight the recent advances on the potential use of anthocyanins in biological systems with particular focus on their photoprotective properties. Topics such as skin aging and eye degenerative diseases, highly influenced by light, and the action of anthocyanins against such damages will be discussed. Photodynamic Therapy and the potential role of anthocyanins as novel photosensitizers will be also a central theme of this review.

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Section: Photodynamic Therapymentioning

confidence: 99%

“…Shi et al have shown the potential use of traditional plants extracts for PDT in the treatment of head and neck squamous cell carcinoma [ 163 ]. From the initial 289 plant extracts, 13 showed high fluorescence properties and were screened for their photo-physical characteristics.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Oliveira

Correia

Pereira

et al. 2020

IJMS

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“…Few fluorescent products have previously been isolated from plants for cellular imaging [ 15 , 16 ]. In our previous studies, we reported that photosensitizers could be extracted from traditional plants and used for photodynamic treatment [ 17 , 18 ]. After treating with photosensitizers, fluorescence was identified around the nucleus where mitochondria are located.…”

Section: Introductionmentioning

confidence: 99%

A Novel Fluorescent Dye Extracted from Buddleja officinalis for Labeling Mitochondria after Fixation

Yang

Kim

et al. 2022

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Mitochondria are versatile organelles and function by communicating with cellular ecosystems. The fluorescent colocalization analysis after fixation is a highly intuitive method to understand the role of mitochondria. However, there are few fluorescent dyes available for mitochondrial staining after fixation. In this study, a novel fluorescent dye (BO-dye), extracted from Buddleja officinalis, was applied for mitochondrial staining in fixed immortalized human oral keratinocytes. The BO-dye (excitation: 414 nm, emission: 677 nm) is a small fluorescent molecular dye, which can cross the cytomembrane without permeabilization. We assume that the BO-dye could aggregate and bind to the mitochondria stably. BO-dye exhibited a mega-Stokes shift (>250 nm), which is an important feature that could reduce self-quenching and enhance the signal-to-noise ratio. Analysis of photophysical properties revealed that the BO-dye is temperature and pH insensitive, and it exhibits superior photostability. These results indicate that BO-dye can be considered an alternative fluorescent dye for labeling mitochondria after fixation.

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“…Currently, only a limited number of PSs are medically approved, most of which are commercially available in small amounts, and in many instances, only a few of them benefit patients entirely in clinical practice. In addition, the practical application of commonly used photophrin related PSs is limited by their slow elimination from the body, consequently resulting in adverse effects such as skin photosensitivity which may persist for weeks after the commencement of the treatment (Shi et al, 2019;Hu et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Effects of Thuja occidentalis on Lung Cancer Cells

et al. 2022

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The global incidence and mortality rates resulting from lung cancer encapsulate a need to identify more effective treatment protocols. Photodynamic therapy (PDT) and homeopathy offer possible anticancer therapies as part of a multi-disciplinary approach. Studies have identified the anticancer effects of Thuja occidentalis L. plant extracts. The aim of this study was to investigate the effects of Thuja occidentalis (TO) homeopathic mother tincture and TO mediated PDT (TO-PDT) on A549 lung cancer cells. Commercially available A549 cells were pre-treated with TO, or laser irradiation at 660 nm, or the combined treatment (TO-PDT). Cells were analyzed morphologically by inverted light microscopy and Hoechst stain; and biochemically by lactate dehydrogenase (LDH), adenosine triphosphate (ATP), and trypan blue assays. Cells treated with TO and TO-PDT demonstrated morphological changes in the cell and cell nuclei indicative of cell death. These groups exhibited a dose dependent increase in LDH release and a decrease in ATP levels and cell viability indicating its cytotoxic and antiproliferative potential. Furthermore, at the same doses, TO when photoactivated in PDT induced enhanced anticancer responses thereby surpassing the effects of treatment with the tincture alone. Results demonstrate how the direct cytotoxic effects of TO can be improved when administered as a photosensitizer in PDT to promote cancer cell death.

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Acanthopanacis Cortex extract: A novel photosensitizer for head and neck squamous cell carcinoma therapy

Cited by 9 publications

References 36 publications

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

A Novel Fluorescent Dye Extracted from Buddleja officinalis for Labeling Mitochondria after Fixation

Photodynamic Effects of Thuja occidentalis on Lung Cancer Cells

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