Acantholysis and spongiosis are associated with loss of syndecan‐1 expression

Bayer‐Garner, Ilene B.; Dilday, Brad; Sanderson, Ralph D.; Smoller, Bruce R.

doi:10.1034/j.1600-0560.2001.028003135.x

Cited by 18 publications

(10 citation statements)

References 20 publications

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“…Spongiotic reaction has been found in several skin lesions (60–64) and in some oral diseases, such as oral melanoacanthosis (melanoacanthoma) (65), oral psoriasis (66), allergic contact stomatitis (67), plasma cell gingivitis, intra‐oral fixed drug eruption, leukoedema and white sponge nevus (68). In most of these oral lesions, the pathogenetic mechanism involved in the collection of the intraepithelial fluid is not clear and remains to be elucidated: spongiosis could be caused by extravasations of fluids from blood vessels located in the lamina propria or by the presence of an osmotic gradient developed towards the epithelium, drawing fluid into it subsequent to various immunological reactions (59).…”

Section: Discussionmentioning

confidence: 99%

Histomorphology of healthy oral mucosa in untreated celiac patients: unexpected association with spongiosis

Campisi¹,

Compilato²,

Iacono³

et al. 2008

J Oral Pathology Medicine

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Our study showed that the healthy oral mucosa of untreated patients does not reflect the intestinal damage by celiac disease, but it is unexpectedly affected by spongiosis, as being detected for the first time in the literature. This latter feature could be related to gliadin ingestion and could contribute to explain the higher susceptibility of celiac disease patients to suffering from oral mucosa lesions.

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Section: Discussionmentioning

confidence: 99%

Histomorphology of healthy oral mucosa in untreated celiac patients: unexpected association with spongiosis

Campisi¹,

Compilato²,

Iacono³

et al. 2008

J Oral Pathology Medicine

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“…In experimental studies of malignant transformation, syndecan-1 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness. Alterations in syndecan expression during development [63] and in transformed epithelial [64,65] are associated with an epithelial-mesenchymal transformation with attendant alterations in cell morphology, motility, growth and differentiation. Transfection of epithelial cells with anti-sense mRNA for syndecan-1 or downregulation of syndecan-1 expression by androgen-induced transformation results in an epithelial to mesenchymal transformation and increased invasion [66-68].…”

Section: Syndecan-1 In Tumor Invasionmentioning

confidence: 99%

Untitled

Beauvais

Rapraeger

2004

Reprod Biol Endocrinol

211

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Anchorage of cells to "heparin" -binding domains that are prevalent in extracellular matrix (ECM) components is thought to occur primarily through the syndecans, a four-member family of transmembrane heparan sulfate proteoglycans that communicate environmental cues from the ECM to the cytoskeleton and the signaling apparatus of the cell. Known activities of the syndecans trace to their highly conserved cytoplasmic domains and to their heparan sulfate chains, which can serve to regulate the signaling of growth factors and morphogens. However, several emerging studies point to critical roles for the syndecans' extracellular protein domains in tumor cell behavior to include cell adhesion and invasion. Although the mechanisms of these activities remain largely unknown, one possibility involves "co-receptor" interactions with integrins that may regulate integrin function and the cell adhesion-signaling phenotype. Thus, alterations in syndecan expression, leading to either overexpression or loss of expression, both of which take place in tumor cells, may have dramatic effects on tumor cell invasion.

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“…We now show that sdc‐1 contributes to the development and progression of skin tumors both in mice and man. Previous reports of sdc‐1 expression in human skin tumors have suggested a correlation between loss of the proteoglycan with increasing invasiveness 22, 24, 25. Remarkably, the loss is detected in both BCC and SCC, tumor types with a markedly different molecular pathogenesis, suggesting that sdc‐1 plays a general role in suppressing cancer development.…”

Section: Discussionmentioning

confidence: 88%

Loss of syndecan‐1 is associated with malignant conversion in skin carcinogenesis

Stepp

Pal‐Ghosh

Tadvalkar

et al. 2010

Molecular Carcinogenesis

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Syndecan-1 (sdc-1) is a cell surface proteoglycan that mediates the interaction of cells with their matrix, influencing attachment, migration and response to growth factors. In keratinocytes, loss of sdc-1 delays wound healing, reduces migration, and increases TGFβ1 expression. In this study we show that sdc-1 expression is significantly reduced in basal cell, squamous cell, and metastatic human skin cancers compared to normal human skin. In experimental mouse skin tumor induction, compared to wildtype (wt) BALB/c mice, papilloma formation in sdc-1 null mice was reduced by 50% and the percent of papillomas converting to squamous cell carcinoma (SCC) was enhanced. Sdc-1 expression on wildtype mouse papillomas decreased as they converted to SCC. Furthermore, papillomas forming on sdc-1 null mice expressed suprabasal α3 and β4 integrins; suprabasal β4 integrin is a marker of a high risk for progression. While the proliferative response to TPA did not differ among the genotypes, sdc-1 null mice had an enhanced inflammatory response and retained higher levels of total TGFβ1 within their skin after TPA treatment. Sdc-1 null keratinocytes, transduced in vitro by oncogenic rasHa, expressed higher levels of β4 integrin and had enhanced pSmad2 signaling and reduced senescence when compared to wildtype rasHa transduced keratinocytes. When rasHa transduced cells of both genotypes were grafted onto nude mice, null tumors converted to SCC with higher frequency confirming the skin painting experiments. These data indicate that sdc-1 is important both early in the development of skin tumors and in progression of skin cancers suggesting that reduced expression of sdc-1 could be a useful marker for progression in neoplastic skin lesions.

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Acantholysis and spongiosis are associated with loss of syndecan‐1 expression

Abstract: The loss of syndecan-1 expression evident in acantholytic conditions and, to a lesser extent in spongiotic conditions, may contribute to the decreased intercellular adhesion characteristic of these lesions.

Cited by 18 publications

References 20 publications

Histomorphology of healthy oral mucosa in untreated celiac patients: unexpected association with spongiosis

Histomorphology of healthy oral mucosa in untreated celiac patients: unexpected association with spongiosis

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Loss of syndecan‐1 is associated with malignant conversion in skin carcinogenesis

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