Acanthamoeba Keratitis

Auran, James D.; Starr, Michael B.

doi:10.1097/00003226-198706010-00002

Cited by 188 publications

(36 citation statements)

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“…Дальнейший про-цесс включает набухание и деструкцию коллагена, гибель кератоцитов вследствие апоптоза, фермента-тивного лизиса, обусловленного протеазами амебы и активацией протеаз хозяина, токсического дей-ствия продуктов цитолиза и иммунных реакций [31,34]. Ранний диагноз очень важен при AK, поскольку заболевание обычно развивается быстро, и отсут-ствие адекватной терапии в течение 3 нед и более считается прогностически неблагоприятным [14]. Oднако в отдельных случаях АК прогрессирует очень медленно (иногда в течение нескольких меся-цев).…”

Section: патогенез акunclassified

“…АК часто ошибочно расценивается как герпети-ческий кератит (ГК), поскольку наблюдаются уме-ренно выраженная инъекция глазного яблока (чаще перикорнеальная) и наличие точечных и субэпите-лиальных инфильтратов, которые, сливаясь, могут образовывать фигуру, напоминающую «веточки де-рева» (так называемый псевдодревовидный кератит) [14,37]. Воспалительный процесс постепенно про-грессирует по глубине и площади роговицы, появ-ляются стромальные изменения и формируются кольцевые инфильтраты белесоватого-серого или белого цвета.…”

Section: клинические признаки акunclassified

“…Тем не менее до настоящего времени вероят-ность диагностических ошибок при клинической диагностике АК остается слишком высокой -22-25% [14,37].…”

Section: клинические признаки акunclassified

“…[5]. Впоследствии были описаны клиниче-ские факторы риска -ношение контактных линз (КЛ) (в развитых странах) или травма и контакт с за-грязненной водой, а также ослабление иммунитета (в развивающихся странах) [11][12][13][14]. В некоторых работах описаны источники возникновения АК: в одной -у пациента с рецидивирующей эрозией ро-говицы, возникшей после плавания в пруду, во вто-рой -после травмы роговицы мелкой металличе-ской стружкой, в третьей -после попадания в глаз воды из загрязненного водоема.…”

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Diagnosis of Acanthamoeba keratitis

Marchenko

Kasparova

2016

Vestn. oftal'mol.

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Section: патогенез акunclassified

Section: клинические признаки акunclassified

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Diagnosis of Acanthamoeba keratitis

Marchenko

Kasparova

2016

Vestn. oftal'mol.

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“…Pathogenic free-living amoebae can cause life-threatening meningoencephalitis or sight-threatening keratitis (1,9,14). The corneal epithelium is affected early in the pathogenesis of Acanthamoeba keratitis.…”

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Apoptosis as a mechanism of cytolysis of tumor cells by a pathogenic free-living amoeba

1994

Parasitology Today

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Previous studies have shown that trophozoites of the pathogenic free-living amoeba Acanthamoeba castellanii rapidly lysed a variety of tumor cells in vitro. Tumor cells undergoing parasite-mediated lysis displayed characteristic cell membrane blebbing reminiscent of apoptosis. The present investigation examined the role of apoptosis (programmed cell death) in Acanthamoeba-mediated tumor cell lysis. The results showed that more than 70%o of tumor cell DNA was fragmented following exposure to Acanthamoeba cell extracts. By contrast, only 7% of untreated control cells underwent DNA fragmentation. DNA fragmentation increased significantly in a dose-dependent fashion following concentration of the parasite extract. Apoptosis was also confirmed by DNA ladder formation. Characteristic DNA ladders, consisting of multimers of approximately 180 to 200 bp, were produced by tumor cells exposed to Acanthamoeba cell extracts. The morphology of tumor cell lysis was examined by light and scanning electron microscopy. Tumor cells exposed to parasite extract displayed morphological features characteristic of apoptosis including cell shrinkage, cell membrane blebbing, formation of apoptotic bodies, and nuclear condensation. By contrast, similar effects were not found in tumor cells exposed to extract similarly prepared from normal mammalian cells (i.e., human keratocytes). The results suggest that at least one species of pathogenic free-living amoeba is able to lyse tumor cells by a process that culminates in apoptosis.Acanthamoeba species are ubiquitous pathogenic free-living protozoal organisms that have been isolated from an unbelievably diverse range of habitats (17).

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Synthesis, Antimicrobial and Antineoplastic Activities for Agelasine and Agelasimine Analogs with a β‐Cyclocitral Derived Substituent

Proszenyák

Charnock

Hedner

et al. 2007

Archiv der Pharmazie

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Agelasines and agelasimines are antimicrobial and cytotoxic purine derivatives isolated from marine sponges (Agelas sp.). We have synthesized structurally simplified analogs of these natural products starting from beta-cyclocitral. The novel compounds were found to be strong inhibitors of a wide variety of pathogenic microorganisms (incl. Mycobacterium tuberculosis) as well as cancer cell lines. The biological activities were generally in the same range as those previously found for the structurally more complex agelasines and agelasimines isolated in small amounts from natural sources. We also report for the first time that agelasine and agelasimine analogs inhibit growth of protozoa (Acanthamoeba castellanii and Acanthamoeba polyphaga). Acanthamoeba keratitis is an increasingly common and severe corneal infection, closely associated with contact lens wear.

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Acanthamoeba Keratitis

Cited by 188 publications

References 0 publications

Diagnosis of Acanthamoeba keratitis

Diagnosis of Acanthamoeba keratitis

Apoptosis as a mechanism of cytolysis of tumor cells by a pathogenic free-living amoeba

Synthesis, Antimicrobial and Antineoplastic Activities for Agelasine and Agelasimine Analogs with a β‐Cyclocitral Derived Substituent

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