2010
DOI: 10.1016/j.exppara.2010.02.004
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Acanthamoeba castellanii: Morphological analysis of the interaction with human cornea

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Cited by 14 publications
(19 citation statements)
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“…), and the initial binding of the parasite leads to secondary events, such as phagocytosis (Omaña‐Molina et al. ) and toxin production (Sissons et al. ).…”
Section: Discussionmentioning
confidence: 99%
“…), and the initial binding of the parasite leads to secondary events, such as phagocytosis (Omaña‐Molina et al. ) and toxin production (Sissons et al. ).…”
Section: Discussionmentioning
confidence: 99%
“…The results observed in this study show that conditioned medium may promote the separation between the cells, leaving small spaces between them, which may facilitate the passage of amoebae between cell junctions. Besides we have proved that conditioned medium alone is able to damage only the most superficial human corneal tissue but amoebae invade and phagocyte epithelial cells reaching the Bowman layer of human cornea [17]. Ruqaiyyah and Khan [35], with reference to contact-independent factors of Acanthamoeba, have mentioned that these amoebae possess hydrolytic enzymes including elastases, phospholipases, glycosidases and a variety of serine, cysteine and metalloproteases, and ensure that their precise mechanisms of action at the molecular level are only beginning to emerge.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, it has also been demonstrated that if Acanthamoeba trophozoites are cocultured with isolated hamster and human corneas, the amoebae are able to invade and cause damage to the intact corneal epithelium, without the requirement of a previous corneal abrasion [17, 18]. …”
Section: Introductionmentioning
confidence: 99%
“…pathogenesis are complex and have not been completely elucidated. The process includes contact-dependent and contact-independent events (Omaña-Molina et al 2010). Among the former, acanthopodia, characteristic of this amoeba, participate in adhesion and tissue invasion, as well as phagocytosis of target cells.…”
Section: Discussionmentioning
confidence: 99%