Açaí (Euterpe oleracea Mart.) reduces the inflammatory response triggered in vitro by the antipsychotic drug olanzapine in RAW 264.7 macrophage cells

Fernandes, Marcelo Adorna; Machado, Alencar Kolinski; Assmann, Charles Elias; Andrade, Eduardo N.C. de; Azzolin, Verônica Farina; Prado-Lima, Pedro Antônio Schmidt do; Riffel, Rogério Tomasi; Maia-Ribeiro, Ednéa Aguiar; Cadoná, Francine Carla; Praia, Raquel de Souza; Barbisan, Fernanda; Cruz, Ivana Beatrice Mânica da

doi:10.17306/j.afs.0857

Cited by 4 publications

(1 citation statement)

References 52 publications

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“…For example, previous investigations carried out by our research team showed that Rotenone-induced mitochondrial dysfunction could be reversed in the presence of açai extract, an Amazon fruit with antioxidant and anti-inflammatory action [33]. Likewise, açai was able to reverse the inflammatory activation of macrophages [49] and microglia [50]. Other studies have also shown that the inflammatory pattern associated with the VV-SOD2 genotype was attenuated in vitro by supplementing cell cultures with lithium [51].…”

Section: Discussionmentioning

confidence: 65%

Superoxide-imbalance Pharmacologically Induced by Rotenone Triggers Behavioral, Neural, and Inflammatory Alterations in the Eisenia fetida Earthworm

et al. 2022

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Section: Discussionmentioning

confidence: 65%

Superoxide-imbalance Pharmacologically Induced by Rotenone Triggers Behavioral, Neural, and Inflammatory Alterations in the Eisenia fetida Earthworm

et al. 2022

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The Relieving Effects of a Polyherb-Based Dietary Supplement ColonVita on Gastrointestinal Quality of Life Index (GIQLI) in Older Adults with Chronic Gastrointestinal Symptoms Are Influenced by Age and Cardiovascular Disease: A 12-Week Randomized Placebo-Controlled Trial

Xing

Zhang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Chronic gastrointestinal symptoms (CGS) negatively affect the quality of life in about 15–30% of the population without effective drugs. Recent studies suggest that dietary supplement may improve CGS, but inconsistent results exist. The goal of this study is to evaluate the effect of a polyherbal-based supplement ColonVita on the gastrointestinal quality of life index (GIQLI) in 100 old adults with CGS (63.1 ± 9.6 years) who were randomly assigned to daily ColonVita or placebo tablets (n = 50/group) for 12 weeks in a double-blind, randomized controlled trial design. No significant fibrdifferences were found between ColonVita and placebo in the baseline total GIQLI score (101.12 ± 16.87 vs. 101.80 ± 16.48) ( P > 0.05 ) or postintervention total GIQLI score (114.78 ± 9.62 vs. 111.74 ± 13.01) ( P > 0.05 ). However, ColonVita significantly improved 16 scores of the 19 core GI symptoms compared with 10 items improved by placebo. The ColonVita group significantly improved the remission rate of 5 core GI symptoms compared to placebo and significantly improved the total GIQLI scores (118.09 ± 7.88 vs. 109.50 ± 16.71) ( P < 0.05 ) and core GI symptom scores (64.61 ± 3.99 vs. 60.00 ± 8.65) ( P < 0.05 ) in people ≥60 years of age (n = 49) but not in those under 60 y (n = 51). ColonVita significantly improved the total GIQLI scores and core GI symptom scores in people without cardiovascular diseases (CVD) (n = 56) (116.74 ± 9.38 vs. 110.10 ± 14.28) ( P < 0.05 ) and (63.11 ± 4.53 vs. 59.93 ± 8.03) ( P = 0.07 ), respectively, but not in those with CVD (n = 44). Thus, ColonVita was beneficial for old adults with CGS, especially those ≥60 years of age and without CVD. Because a heterogenous pathogenesis of CGS-like irritable bowel syndrome (IBS) and inflammatory bowel disease (ISD) is differentially associated with CVD, different comorbidities may have influenced the outcomes of different trials that should be controlled in further studies.

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Superoxide-imbalance pharmacologically induced by Rotenone triggers behavioral, neural, and inflammatory alterations in the Eisenia fetida earthworm

Mastella

Roggia

Turra

et al. 2021

Preprint

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Background: The inflammatory theory of depression has been tested from epidemiological and experimental investigations. Some studies have suggested that mitochondrial dysfunction superoxide imbalance could increase the susceptibility to chronic stressful events, contributing to the establishment of chronic inflammation and the development of mood disorders. If this premise is true, mitochondrial superoxide imbalance induced by some molecules, such as Rotenone could be evolutionary conservated causing behavioral, immune, and neurological alterations in animals with the primitive central nervous system. Objective: To test this hypothesis, we analyzed some behavioral, immune, and histological markers in Eisenia fetida earthworms chronically exposed to Rotenone, that causes mitochondrial impairment for 14 days. Methods: earthworms were put in an artificial soil containing 30 nM of Rotenone distributed into a plastic cup that allowed the earthworms to leave and return freely into the ground. Since these organisms prefer to be buried in the ground, the model predicted that the earthworm would necessarily have to return to the Rotenone-contaminated medium creating a stressful condition. The effect on survival behavior, in the immune and histological body wall and ventral nervous ganglia (VNG) structures were evaluated, as well gene expression related to inflammation, mitochondrial and neuromuscular changes. Results: Rotenone-induced loss of earthworm escape behavior triggered by boric acid presence; it caused immune alterations indicatives of chronic inflammatory states. Some histological changes in the body wall and VNG indicated a possible earthworm reaction aimed at protection against Rotenone. Overexpression of the nicotinic acetylcholine receptor gene (nAChRs α5) in neural tissues could also help earthworms to reduce the degenerative impact of Rotenone on dopaminergic neurons. Conclusion: The data suggest that mitochondrial dysfunction could be an evolutionarily conserved element in inducing inflammatory and behavioral changes related to exposure to chronic stress.

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Açaí (Euterpe oleracea Mart.) reduces the inflammatory response triggered in vitro by the antipsychotic drug olanzapine in RAW 264.7 macrophage cells

Cited by 4 publications

References 52 publications

Superoxide-imbalance Pharmacologically Induced by Rotenone Triggers Behavioral, Neural, and Inflammatory Alterations in the Eisenia fetida Earthworm

Superoxide-imbalance Pharmacologically Induced by Rotenone Triggers Behavioral, Neural, and Inflammatory Alterations in the Eisenia fetida Earthworm

The Relieving Effects of a Polyherb-Based Dietary Supplement ColonVita on Gastrointestinal Quality of Life Index (GIQLI) in Older Adults with Chronic Gastrointestinal Symptoms Are Influenced by Age and Cardiovascular Disease: A 12-Week Randomized Placebo-Controlled Trial

Superoxide-imbalance pharmacologically induced by Rotenone triggers behavioral, neural, and inflammatory alterations in the Eisenia fetida earthworm

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