Açaí (Euterpe oleracea Mart.) has anti-inflammatory potential through NLRP3-inflammasome modulation

Machado, Alencar Kolinski; Cadoná, Francine Carla; Assmann, Charles Elias; Andreazza, Ana Cristina; Duarte, Marta Maria Medeiros Frescura; Branco, Cátia Santos; Zhou, Xinyang; Souza, Diulie Valente de; Ribeiro, Euler Esteves; Cruz, Ivana Beatrice Mânica da

doi:10.1016/j.jff.2019.03.034

Cited by 35 publications

(25 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Aqueous ethanolic AB extracts restored mitochondrial complex I function by modulating NADH:ubiquinone oxidoreductase core unit 7 and 8 expression. NLRP3 (a component of inflammasome) and caspase 1/caspase 3/caspase 8 (Interleukin-1 converting enzyme family, which initiates inflammatory response) were downregulated in oxidative-agent-treated macrophages [ 313 ]. AB supplementation also interfered with hepatic cholesterolemic metabolism.…”

Section: Acai Berriesmentioning

confidence: 99%

See 1 more Smart Citation

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

et al. 2020

View full text Add to dashboard Cite

Berries are considered “promising functional fruits” due to their distinct and ubiquitous therapeutic contents of anthocyanins, proanthocyanidins, phenolic acids, flavonoids, flavanols, alkaloids, polysaccharides, hydroxycinnamic, ellagic acid derivatives, and organic acids. These polyphenols are part of berries and the human diet, and evidence suggests that their intake is associated with a reduced risk or the reversal of metabolic pathophysiologies related to diabetes, obesity, oxidative stress, inflammation, and hypertension. This work reviewed and summarized both clinical and non-clinical findings that the consumption of berries, berry extracts, purified compounds, juices, jams, jellies, and other berry byproducts aided in the prevention and or otherwise management of type 2 diabetes mellitus (T2DM) and related complications. The integration of berries and berries-derived byproducts into high-carbohydrate (HCD) and high-fat (HFD) diets, also reversed/reduced the HCD/HFD-induced alterations in glucose metabolism-related pathways, and markers of oxidative stress, inflammation, and lipid oxidation in healthy/obese/diabetic subjects. The berry polyphenols also modulate the intestinal microflora ecology by opposing the diabetic and obesity rendered symbolic reduction of Bacteroidetes/Firmicutes ratio, intestinal mucosal barrier dysfunction-restoring bacteria, short-chain fatty acids, and organic acid producing microflora. All studies proposed a number of potential mechanisms of action of respective berry bioactive compounds, although further mechanistic and molecular studies are warranted. The metabolic profiling of each berry is also included to provide up-to-date information regarding the potential anti-oxidative/antidiabetic constituents of each berry.

show abstract

Section: Acai Berriesmentioning

confidence: 99%

“…The expression levels of the pro-inflammatory factors NF-κB, TNF-α, MCP-1 (−0.81%), IL-6 (−0.48%), IL-8 (−0.05%), IL-1βß (−0.03%), and INF-β(−0.49%) were also reduced. TNF-α activates NF-κB and interleukins (IL-2 and IL-6), which was prevented by ABJ polyphenols [ 170 , 313 , 314 ].…”

Section: Acai Berriesmentioning

confidence: 99%

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It was demonstrated that C57BL/6 mice exposed to cigarette smoke and treated with hydroalcoholic fruit extract showed a lower number of neutrophils and macrophages in the lung when compared to the control group, which demonstrates the anti-inflammatory activity of the açaí fruit extract [ 17 ]. Other experiments showed that both dried and frozen hydroalcoholic extract of the fruit pulp interfered with the activation and proliferation of macrophages, promoting the arrest of the cell cycle due to the reduction of NOD-like receptor family pyrin domain containing protein 3 (NLRP3) activation [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…The anti-inflammatory activity of açaí is often associated with the presence of flavonoids, such as catechin and epicatechin, both in the pulp fruit [ 18 ] and in the seeds [ 19 ]. Catechin’s anti-inflammatory effect is well described alone, acting via the regulation of Toll-like receptor (TLR) 2/4 and inflammasome signaling [ 20 ], or in combination with other compounds, suppressing the production of inflammatory cytokines in mouse macrophages in vitro in association with baicalin and β-caryophyllene [ 21 ], and inhibiting the activation of TLR4-MyD88-mediated nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen activated protein kinase (MAPK) signaling pathways in RAW 264.7 macrophages in association with quercetin [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Catechin-Rich Açaí Seed Extract on LPS-Stimulated RAW 264.7 Cells and Carrageenan-Induced Paw Edema

Xavier

Teles

Tellis³

et al. 2021

Foods

View full text Add to dashboard Cite

Açaí berry is a fruit from the tree commonly known as açaízeiro (Euterpe oleracea Mart.) originated from the Amazonian region and widely consumed in Brazil. There are several reports of the anti-inflammatory activity of its pulp and few data about the seed’s potential in inflammation control. This work aimed to evaluate the effect of catechin-rich açaí extract on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and carrageenan-induced paw edema. The treatment with E. oleracea ethyl acetate extract (EO-ACET) was used in an in vitro model performed with macrophages stimulated by LPS, in which pro-inflammatory markers were evaluated, and in an in vivo model of acute inflammation, in which edema inhibition was evaluated. EO-ACET showed an absence of endotoxins, and did not display cytotoxic effects in RAW 264.7 cells. LPS-stimulated cells treated with EO-ACET displayed low levels of nitrite and interleukins (IL’s), IL-1β, IL-6 and IL-12, when compared to untreated cells. EO-ACET treatment was able to inhibit carrageenan-induced paw edema at 500 and 1000 mg/kg, in which no acute inflammatory reaction or low mast cell counts were observed by histology at the site of inoculation of λ-carrageenan. These findings provide more evidence to support further studies with E. oleracea seeds for the treatment of inflammation.

show abstract

“…Most in vitro studies report positive results of the ORAC assay and decreased ROS production even when the cell line used was exposed to lipopolysaccharides. Machado et al [ 57 ] observed a reduction in the activation of murine RAW 264.7 macrophage line cells induced by the treatment with an EO hydroalcoholic extract, due to a decreased activation of nod-like receptor pyrin containing 3 (NLRP3). In another study, Poulose et al [ 31 ], using BV-2 murine microglial cells, observed that the p38 mitogen-activated protein kinase (p38-MAPK) and the transcription factor NF-kB had their activities attenuated by EO, which regulated the production of Ca 2+ -independent nitric oxide synthase (iNOS) as well as the activation of cyclooxygenase 2 (COX -2).…”

Section: Biological Eo Activities: Application In the Prevention Amentioning

confidence: 99%

The Use of Euterpe oleracea Mart. As a New Perspective for Disease Treatment and Prevention

et al. 2020

View full text Add to dashboard Cite

Euterpe oleracea Mart. (EO), popularly known as açaí, belongs to the Arecaceae family and grows abundantly in Brazil. The fruit of this palm tree is widely used because of its anti-inflammatory and antioxidant properties. In this review, a search for literature and patent technological prospecting has been performed on the use of EO to treat and prevent diseases as well as to prepare pharmaceutical formulations. EO leaves, fruits, and oil stand out for their large number of pharmacological activities such as anti-inflammatory, antioxidant, antimicrobial, antinociceptive, anticancer, anti-atherogenic, and healing activities, protection against metabolic syndromes such as diabetes, hypertension, and hyperlipidemia, and protection of organs such as lung, kidney, liver, heart, and nervous system. While the phytochemical composition is intrinsically linked to identified biological activities, discoveries of the past decade concerning the use of this species have shown pharmacological alternatives mainly in the treatment and prevention of breast cancer and metabolic syndromes. Although studies and inventions on the use of EO though are believed to have been important in light of the pharmacological activities found, few clinical and toxicity tests have been performed. Nevertheless, with the increase of interest in EO, this species is believed to be only at the beginning of the breakthroughs in the development of promising products for the pharmaceutical industry.

show abstract

Açaí (Euterpe oleracea Mart.) has anti-inflammatory potential through NLRP3-inflammasome modulation

Cited by 35 publications

References 53 publications

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications

Inhibitory Effect of Catechin-Rich Açaí Seed Extract on LPS-Stimulated RAW 264.7 Cells and Carrageenan-Induced Paw Edema

The Use of Euterpe oleracea Mart. As a New Perspective for Disease Treatment and Prevention

Contact Info

Product

Resources

About