Açai Berry Mitigates Parkinson’s Disease Progression Showing Dopaminergic Neuroprotection via Nrf2-HO1 Pathways

D’Amico, Ramona; Impellizzeri, Daniela; Genovese, Tiziana; Fusco, Roberta; Peritore, Alessio Filippo; Crupi, Rosalia; Interdonato, Livia; Franco, Gianluca Antonio; Marino, Ylenia; Arangia, Alessia; Gugliandolo, Enrico; Cuzzocrea, Salvatore; Paola, Rosanna Di; Siracusa, Rosalba; Cordaro, Massimiliano

doi:10.1007/s12035-022-02982-5

Cited by 17 publications

(15 citation statements)

References 90 publications

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“…The Açai Berry supplementation reduced the lesion area, volume and diameter. From the molecular point of view, the endometrial microenvironment was characterized by dysregulated autophagic, oxidative balance and apoptotic pathways [ 33 , 67 , 68 ].…”

Section: Discussionmentioning

confidence: 99%

Complex Interplay between Autophagy and Oxidative Stress in the Development of Endometriosis

et al. 2022

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Endometriosis (Endo) is a chronic gynecological disease. This paper aimed to evaluate the modulation of autophagy, oxidative stress and apoptosis with Açai Berries in a rat model of endometriosis. Endometriosis was induced with an intraperitoneal injection of minced uterus tissue from a donor rat into a recipient one. The abdominal high-frequency ultrasound (hfUS) analysis was performed at 7 and 14 days from the endometriosis induction to evaluate the growth of the lesion during the experiment. Seven days from the induction, once the lesions were implanted, an Açai Berry was administered daily by gavage for the next seven days. At the end of the experiment, the hfUS analysis showed a reduced lesion diameter in animals given the Açai Berry. A macroscopical and histological analysis confirmed this result. From the molecular point of view, Western blot analyses were conducted to evaluate the autophagy induction. Samples collected from the Endo group showed impaired autophagy, while the Açai Berry administration inhibited PI3K and AKT and ERK1/2 phosphorylation and promoted autophagy by inactivating mTOR. Additionally, Açai Berry administration dephosphorylated ATG1, promoting the activity of the ATG1/ULK1 complex that recruited Ambra1/Beclin1 and Atg9 to promote autophagosome nucleation and LC3II expression. Açai Berry administration also restored mitophagy, which increased Parkin cytosolic expression. The Açai Berry increased the expression of NRF2 in the nucleus and the expression of its downstream antioxidant proteins as NQO-1 and HO-1, thereby restoring the oxidative imbalance. It also restored the impaired apoptotic pathway by reducing BCL-2 and increasing BAX expression. This result was also confirmed by the TUNEL assay. Overall, our results displayed that Açai Berry administration was able to modulate autophagy, oxidative stress and apoptosis during endometriosis.

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Section: Discussionmentioning

confidence: 99%

Complex Interplay between Autophagy and Oxidative Stress in the Development of Endometriosis

et al. 2022

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“…The bladder, testes, blood, sperm, and serum were collected. The dose of açai berry was calculated based on our previously published works [ 65 , 66 , 67 ].…”

Section: Methodsmentioning

confidence: 99%

Açai Berry Attenuates Cyclophosphamide-Induced Damage in Genitourinary Axis-Modulating Nrf-2/HO-1 Pathways

et al. 2022

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Cyclophosphamide (CYP) is used to treat different malignancies and autoimmune disorders in men. This chemotherapy frequently reduces tumors, which is beneficial, but also causes infertility because of severe oxidative stress, inflammation, and apoptosis in the bladder and testes brought on by its metabolite, acrolein. The goal of this study was to assess the efficacy of a novel food, açai berry, in preventing CYP-induced damage in the bladder and testes. Methods: CYP was administered intraperitoneally once during the experiment at a dose of 200 mg/kg body weight diluted in 10 mL/kg b.w. of water. Açai berry was administered orally at a dose of 500 mg/kg. Results: The administration of açai berry was able to reduce inflammation, oxidative stress, lipid peroxidation, apoptosis, and histological changes in the bladder and testes after CYP injection. Conclusions: Our findings show for the first time that açai berry modulates physiological antioxidant defenses to protect the bladder and testes against CYP-induced changes.

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“…The enhancer sequences known as antioxidant response elements (AREs), which are found in the regulatory regions of Nrf2 target genes. Nrf2 coordinates the expression of several genes, including not only genes encoding antioxidant enzymes but also a series of genes involved in various processes including respiratory, cerebrovascular, and neurodegenerative diseases [9][10][11]. In Figure 2, the mechanism of action of Nrf2 is clearly demonstrated.…”

Section: Nrf2mentioning

confidence: 99%

“…(8) However, if the insulin receptor signaling is initiated, GSK-3β activity is inhibited. (9) Keap1 is also able to regulate Nrf2 activity through sequestration with PGAM5 to the mitochondria [12].…”

Section: Nrf2mentioning

confidence: 99%

“…Also, in this study, the authors observed a significantly improvement in both motor and non-motor deficits, histological alteration, pro-inflammatory cytokine release, neutrophilic infiltration, and lipid peroxidation limiting dopaminergic neuronal death [48]. Some studies, additionally, have shown Açai berries' anti-inflammatory properties in a model of co-culture between Caco-2 and RAW 264.7 macrophages, which has the potential to prevent intestinal inflammatory diseases, due to anthocyanin improved Tight Junction barrier integrity and reduce gastrointestinal inflammation by preventing the expression of cytokines, especially IL-6, IL-8, and PGE2 through inhibition of COX-2 [49]. Açai barriers can also be used for anti-inflammatory treatment of bone diseases such as periodontal disease are triggered by chronic inflammation causing the upregulation of osteoclastogenesis.…”

Section: Açai Berrymentioning

confidence: 99%

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Dietary Regulation of Keap1/Nrf2/ARE Pathway: Focus on Acai Berries and Pistachios and Cashews as Natural Food Sources

Paola¹,

Cuzzocrea²,

Fusco³

et al. 2023

Biochemistry

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Inflammation is a biological reaction to oxidative stress in which cell starts producing proteins, enzymes, and other substances to restore homeostasis, while oxidative stress could be intrinsically a biochemical imbalance of the physiologically redox status of the intracellular environment. The nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway, which controls the transcription of numerous antioxidant genes that protect cellular homeostasis and detoxification genes that process and eliminate all toxic compounds and substances before they can cause damage. The Nrf2 pathway is the heart of the daily biological response to oxidative stress. Transient activation of Nrf2 by diet can upregulate antioxidant enzymes to protect cells against oxidative stress inducers. In this chapter, we summarize the effects of some novel foods in the regulation of the Nrf2/ARE pathway and its cellular mechanisms.

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Açai Berry Mitigates Parkinson’s Disease Progression Showing Dopaminergic Neuroprotection via Nrf2-HO1 Pathways

Cited by 17 publications

References 90 publications

Complex Interplay between Autophagy and Oxidative Stress in the Development of Endometriosis

Complex Interplay between Autophagy and Oxidative Stress in the Development of Endometriosis

Açai Berry Attenuates Cyclophosphamide-Induced Damage in Genitourinary Axis-Modulating Nrf-2/HO-1 Pathways

Dietary Regulation of Keap1/Nrf2/ARE Pathway: Focus on Acai Berries and Pistachios and Cashews as Natural Food Sources

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