Academic performance in adolescents born after ART—a nationwide registry-based cohort study

Spangmose, Anne Lærke; Malchau, Sara Sofia; Schmidt, Lone; Vassard, Ditte; Rasmussen, Steen; Loft, Anne; Forman, Julie Lyng; Pinborg, Anja

doi:10.1093/humrep/dew334

Cited by 36 publications

(33 citation statements)

References 41 publications

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“…Of the 60 eliminated papers, 16 reported on only ICSI‐ compared to IVF‐conceived offspring and have been discussed previously {Catford:2017gj}, and seven reported on ICSI‐conceived offspring without a SC‐ or IVF‐conceived control group (Bonduelle et al ., ; Pruksananonda, ; Neri et al ., ; De Schepper et al ., ; Belva et al ., ; Tsai et al ., , ). Two studies did not directly compare ICSI and SC children (Schendelaar et al ., ; Spangmose et al ., ). A further 35 papers were eliminated; details of their exclusion rationale are as previously published (Catford et al ., ).…”

Section: Resultsmentioning

confidence: 97%

Long‐term follow‐up of ICSI‐conceived offspring compared with spontaneously conceived offspring: a systematic review of health outcomes beyond the neonatal period

et al. 2018

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Background: A significant increase in the use of intracytoplasmic sperm injection (ICSI) since its introduction in 1992 has been observed worldwide, including beyond its original intended use for severe male factor infertility. Concerns regarding ICSI include the effects of poor quality spermatozoa on offspring health and future fertility, and of the technique itself. The health and development of ICSI-conceived children beyond early infancy have not been comprehensively assessed. Objective: A systematic review of health outcomes of ICSI-conceived offspring beyond the neonatal period compared to spontaneously conceived (SC) offspring. Design: PubMed, OVID Medline/Embase, InformIT, Web of Science, and ProQuest databases were searched for studies reporting on health outcomes in ICSI-conceived offspring beyond 28 days after birth. Main outcomes measure(s): Physical and psychosocial health. Results: The search strategy yielded 2826 articles. Of these, 2580 were not relevant or did not meet inclusion criteria and 138 were duplicates. One hundred and eight full-text papers were evaluated further, and 48 satisfied the inclusion criteria. Most studies reported on neurodevelopment during early infancy and childhood with reassuring results. Growth, vision, and hearing of ICSI and SC offspring also appear comparable, although important differences in general physical health, and particularly metabolic and reproductive health have been described, including recently poorer semen quality among ICSI-conceived young adult men compared to SC peers. Conclusion: Whilst neurodevelopment, growth, vision, and hearing appear similar between ICSI and SC children, evidence suggests differences in general physical health, and metabolic and reproductive endpoints. The clinical significance of many findings, however, remains unclear, and further prospective, large, and good quality studies with a focus on all these health outcomes in ICSIconceived young adults are required.

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Section: Resultsmentioning

confidence: 97%

Long‐term follow‐up of ICSI‐conceived offspring compared with spontaneously conceived offspring: a systematic review of health outcomes beyond the neonatal period

et al. 2018

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“…Previous studies on the association of ICSI with IQ or academic performance are inconsistent . However, in 2017, this research group published a large cohort study of 4766 ART adolescents born from 1995 to 1998 showing no difference in academic performance between IVF and ICSI adolescents . In our sensitivity analyses, stratified on fertilisation method, FET‐IVF, or FET‐ICSI did not affect the mean differences in test scores.…”

Section: Discussionmentioning

confidence: 99%

“…This cohort is an extended population of a cohort used in a previous study by our group exploring academic performance in children born after fresh ET versus spontaneous conception (SC). 24 In the present study, we extended the study period by 3 years (1999-2001) to obtain sufficient statistical power in the analyses of children conceived after FET. All FET children were conceived after embryo preservation using slow freezing techniques as vitrification was not used in Denmark during the period included in the study.…”

Section: Study Populationmentioning

confidence: 99%

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Academic performance in adolescents aged 15–16 years born after frozen embryo transfer compared with fresh embryo transfer: a nationwide registry‐based cohort study

Spangmose

Malchau

Henningsen

et al. 2018

BJOG

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Objective To assess academic performance in singletons aged 15–16 years conceived after frozen embryo transfer (FET) compared with singletons born after fresh embryo transfer (ET) in Danish cohorts born from 1995 to 2001. Design Danish national registry‐based cohort study. Setting Danish national registries. Population All 6495 singletons conceived after assisted reproductive technology (ART) treatment in Denmark from 1995 to 2001 [FET (n) = 423; fresh ET (n) = 6072]. Methods Mean test scores on a national standardised and international comparable grading‐scale. Comparisons of test score were first made in univariate analysis (Model 1) and secondly in a multivariate linear model (Model 2) adjusting for relevant reproductive and socio‐demographic covariates such as the occupational and educational level of the parents. Sensitivity analyses on FET‐IVF (in vitro fertilisation) versus fresh ET‐IVF and FET‐ICSI (intracytoplasmic sperm injection) versus fresh ET‐ICSI were made. Linear mixed models were used to account for the correlation in test scores of siblings for continuous outcome. Main outcome measures Mean overall test score and test score in Danish, mathematics, English, and physics/chemistry. Results Crude and adjusted mean test scores were similar for adolescents conceived after FET compared with fresh ET. The crude mean difference was +0.11 (95% CI −0.11; 0.34), and the adjusted mean difference was +0.12 (95% CI −0.09; 0.34). Conclusions Adolescents conceived after FET had similar academic performance at 15–16 of years of age compared with children conceived after fresh ET. Tweetable abstract Using frozen embryos in fertility treatment does not affect school performance in Danish adolescents aged 15–16 years.

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“…20 In general, the long-term mental and emotional health outcomes, including school performance, for children born from ART are reassuring, and are very similar to those of spontaneously conceived children. 21,22 A systematic review and meta-analysis reported cardiovascular and metabolic profiles in offspring conceived by ART, and it showed slightly higher blood pressure and altered cardiovascular function. 23 These findings are based on very small studies and need to be confirmed in larger controlled cohort studies.…”

Section: Long-term Health Outcomes Of Children Conceived By Artmentioning

confidence: 99%

Short‐ and long‐term outcomes in children born after assisted reproductive technology

Pinborg

2018

BJOG

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It has been forty years since the first IVF child, Louise Brown, born in 1978 and now more than 7 million children are conceived after assisted reproductive technologies (ART). There has been a tremendous increase in the number of ART cycles and several more advanced treatments have been developed, such as intracytoplasmic sperm injection (ICSI). ICSI revolutionized the treatment of severe male factor infertility after the first ICSI baby born in 1992. This article is protected by copyright. All rights reserved.

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Academic performance in adolescents born after ART—a nationwide registry-based cohort study

Abstract: 704676.

Cited by 36 publications

References 41 publications

Long‐term follow‐up of ICSI‐conceived offspring compared with spontaneously conceived offspring: a systematic review of health outcomes beyond the neonatal period

Long‐term follow‐up of ICSI‐conceived offspring compared with spontaneously conceived offspring: a systematic review of health outcomes beyond the neonatal period

Academic performance in adolescents aged 15–16 years born after frozen embryo transfer compared with fresh embryo transfer: a nationwide registry‐based cohort study

Short‐ and long‐term outcomes in children born after assisted reproductive technology

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