Acacia seyal Del Bark Extract Reduces Quorum Sensing –Controlled Virulence Factor Production and Biofilm Formation in Pseudomonas aeruginosa PAO1

Abstract

Due to the various virulence factors produced and the growing resistance to antibiotics, Pseudomonas aeruginosa is the major cause of mortality in immunocompromised patients. Its pathogenicity regulated by the QS system lead to consider this mechanism of bacterial communication an opportunity for the control of infections caused by bacteria resistant to antibiotics. Thus, the ability of Acacia seyal bark extract to disrupt the cell-to-cell communication, to inhibit the production of virulence factors and biofilm formation was assessed in Pseudomonas aeruginosa PAO1. These investigations demonstrated that A. seyal bark extract inhibited significantly the production of QScontrolled virulence factors and biofilm formation without negatively affecting the growth of P. aeruginosa PAO1. These results suggest that A. seyal quenches the quorum sensing mechanism and could be a potent source for the research of new effective anti-QS drugs.

The Molecular Architecture of Pseudomonas aeruginosa Quorum-Sensing Inhibitors

“…The extracts of Citrus sinensis , Laurus nobilis , Allium cepa , Elettaria cardamomum , and Coriandrum sativum also show potent quorum-quenching effects on P. aeruginosa and eliminate pyocyanin formation [ 154 ]. In addition, Acacia seyal Del Bark extracts and plantain herb extracts affect QS-controlled extracellular virulence factors production [ 54 , 155 ]. Piper nigrum containing phenolic and flavonoid components, Punica granatum containing tannins and alkaloids, and Pisum sativum containing tannins and phenolic compounds have quorum-sensing inhibitory activity and can control the formation of biofilm [ 156 ].…”

African Plant-Based Natural Products with Antivirulence Activities to the Rescue of Antibiotics

“…& Perr. (Combretaceae) [ 48 ], traditionally used for the treatment of respiratory tract diseases, skin diseases and wounds; Vachellia seyal (Delile) P.J.H.Hurter (synonym of Acacia seyal Delile) Del (Fabaceae) [ 47 ] traditionally used to treat toothache, dysentery, and burns [ 62 ] with reported potent antimicrobial activity [ 63 ]; and Zanthoxylum zanthoxyloides (Lam) Zepern. and Timler (Rutaceae) also used to treat typhoid fever, respiratory infections, infected wounds, and dental diseases [ 46 ].…”