Acacetin Alleviates Hepatitis Following Renal Ischemia–Reperfusion in Male Balb/C Mice by Antioxidants Regulation and Inflammatory Markers Suppression

Jalili, Cyrus; Akhshi, Nasim; Raissi, Farshid; Shiravi, Abdolhossein; Alvani, Alvand; Vaezi, Gholamhassan; Nedaei, Seyed Ershad; Ghanbari, Ali

doi:10.1080/08941939.2019.1656309

Cited by 13 publications

(9 citation statements)

References 37 publications

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“…Nitrite oxide, as a common free radical in mammalian cells, interferes with physiological processes. Hydroxyl radicals are formed by nitrite oxide and superoxide anions in the pathogenesis procedure (5). The decline in nitrite oxide levels is attributed to the lower expression of iNOS.…”

Section: Discussionmentioning

confidence: 99%

“…Also, we showed a high positive association between nitrite oxide and TNF-α, IL-1β, and TLR-4 expression in pancreatitis, which was reduced by AJ administration. This is considered a complicated event when Jalili and colleagues analyzed the collaboration between TNF-α, TLR-4, and IL-6 in the Acacetine-induced safety cascade in hepatitis subsequent ischemia-reperfusion (5). This study exclusively examined the probable relationship between IL-1β and TLR-4 or its dependence in the case of γ-radiation and AJ administarion.…”

Section: Discussionmentioning

confidence: 99%

“…In each stage of lipid peroxidation, a large amount of oxidative stress is formed, especially in the cell membrane, cell lipoproteins, and the membrane of organelles. This detrimental process leads to cell toxicity and deactivation of enzymatic antioxidant through two main intermediates; peroxidation and hydroxylation (5). Basically, there are two sources of oxidative stress production, namely endogenous and exogenous sources.…”

Section: Introductionmentioning

confidence: 99%

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Radioprotective Effects of Allium jesdianum Extract on Reduction of Pancrease Damages Following γ-Radiation through Down-regulation of Apoptotic Genes, Antioxidants Regulation, and Suppression of Inflammatory Markers

Roshankhah

Zahabi

Gholami

et al. 2021

Jundishapur J Nat Pharm Prod

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Background: Allium jesdianum (AJ), as a plant in onion category, has antioxidant features. Moreover, γ-ray potentially generates oxidative stress in living organisms. Objectives: In this study, the probable therapeutic effects of AJ on destruction of pancreas tissue following γ-ray were evaluated. Methods: Sixty-four mature NMRI mice (8 animals in each group) were assigned to eight groups as follows: (1) Control; (2) γ-ray (dose rate of 1 Gy/min); (3-5) AJ extract (500, 1,000, and 2,000 mg/kg); and (6-8) AJ + γ-ray. AJ extract was prepared, and all administrations were applied orally for 70 consecutive days. Antioxidant parameters (nitrite oxide, peroxidation, and ferric reducing ability of plasma (FRAP)), the expression of apoptotic genes (p53 and Bax, by quantitative real-time PCR), and blood concentrations of glucose and insulin were determined biochemically and genetically. Inflammatory cytokines were evaluated by ELISA technique. The number and diameter of Langerhan islets were also studied histologically. Results: In this study, γ-ray increased the levels of all parameters significantly (except for FRAP, insulin, and morphometric parameters, which were reduced) in the γ-ray group compared to the control group (P < 0.05). In the γ-ray and AJ + γ-ray groups, all factors were reduced significantly (except for FRAP, insulin, and morphometric parameters, which were increased) compared to the γ-ray group (P < 0.05). Conclusions: Administration of AJ extract can decrease the damage and radiosensitization in pancreatic cells induced by γ-ray.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Radioprotective Effects of Allium jesdianum Extract on Reduction of Pancrease Damages Following γ-Radiation through Down-regulation of Apoptotic Genes, Antioxidants Regulation, and Suppression of Inflammatory Markers

Roshankhah

Zahabi

Gholami

et al. 2021

Jundishapur J Nat Pharm Prod

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“…Collaboration in TNFα, IL-6, and TLR-4 is observed in protection cascade induced by Acacetin through antioxidants regulation in hepatitis subsequent ischemia-reperfusion (Figure 3; Jalili et al, 2021).…”

Section: Hepatoprotective Potentialmentioning

confidence: 96%

Date fruit as a promising source of functional carbohydrates and bioactive compounds: A review on its nutraceutical potential

Alvi

Khan

Maan

et al. 2022

Journal of Food Biochemistry

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“…et Kir.) Sch.-Bip., with antiarrhythmic [ 193 ], antitumor [ 194 , 195 ], anti-inflammatory [ 196 ], antifibrosis [ 197 ], and antioxidation [ 198 ]. In terms of antiarrhythmia, acacetin is a kind of potassium channel inhibitor without effect on the Na(+) and L-type Ca (2+) channels.…”

Section: Natural Products With Bioactivity In Afmentioning

confidence: 99%

Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels

Ding

et al. 2022

Cardiovascular Therapeutics

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Antiarrhythmic drugs (AADs) have a therapeutic effect on atrial fibrillation (AF) by regulating the function of ion channels. However, several adverse effects and high recurrence rates after drug withdrawal seriously affect patients’ medication compliance and clinical prognosis. Thus, safer and more effective drugs are urgently needed. Active components extracted from natural products are potential choices for AF therapy. Natural products like Panax notoginseng (Burk.) F.H. Chen, Sophora flavescens Ait., Stephania tetrandra S. Moore., Pueraria lobata (Willd.) Ohwi var. thomsonii (Benth.) Vaniot der Maesen., and Coptis chinensis Franch. have a long history in the treatment of arrhythmia, myocardial infarction, stroke, and heart failure in China. Based on the classification of chemical structures, this article discussed the natural product components’ therapeutic effects on atrial fibrillation by regulating ion channels, connexins, and expression of related genes, in order to provide a reference for development of therapeutic drugs for atrial fibrillation.

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Acacetin Alleviates Hepatitis Following Renal Ischemia–Reperfusion in Male Balb/C Mice by Antioxidants Regulation and Inflammatory Markers Suppression

Cited by 13 publications

References 37 publications

Radioprotective Effects of Allium jesdianum Extract on Reduction of Pancrease Damages Following γ-Radiation through Down-regulation of Apoptotic Genes, Antioxidants Regulation, and Suppression of Inflammatory Markers

Radioprotective Effects of Allium jesdianum Extract on Reduction of Pancrease Damages Following γ-Radiation through Down-regulation of Apoptotic Genes, Antioxidants Regulation, and Suppression of Inflammatory Markers

Date fruit as a promising source of functional carbohydrates and bioactive compounds: A review on its nutraceutical potential

Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels

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