Acacetin, a Natural Flavone, Selectively Inhibits Human Atrial Repolarization Potassium Currents and Prevents Atrial Fibrillation in Dogs

Li, Gui-Rong; Wang, Hongbing; Qin, Guo‐Wei; Jin, Man-Wen; Tang, Qiang; Sun, Hai‐Ying; Du, Xiaona; Deng, Xingming; Zhang, Xiaohua; Chen, Jingbo; Chen, Lei; Xu, Xiaohui; Cheng, Lin; Chiu, SW; Tse, Hung‐Fat; Vanhoutte, Paul M.; Lau, Chu‐Pak

doi:10.1161/circulationaha.108.769554

Cited by 115 publications

(125 citation statements)

References 51 publications

(47 reference statements)

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“…The study demonstrated that the natural compound acacetin is an atrium-selective agent that prolongs the atrial effective refractory period without prolonging the corrected QT interval and effectively prevents AF in anesthetized dogs after intraduodenal administration. These results indicated that oral acacetin is a promising atrium-selective agent for the treatment of AF [66].…”

Section: Acacetinmentioning

confidence: 75%

Antioxidant Properties of Honey and Its Role in Preventing Health Disorder

Khalil¹,

Sulaiman²,

Boukraa³

2010

TONUTRAJ

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Honey is being used since long time both in medical and domestic needs, but only recently its antioxidant property has come to limelight. With increasing demand for antioxidant supply in the food, honey is becoming popular as a source of antioxidant since it is rich in phenolic acids and flavonoids and other antioxidants including glucose oxidase, catalase, ascorbic acid, carotenoid derivatives, organic acids, amino acids and proteins. The antioxidants have several preventative effects against different diseases like cancer, cardiovascular diseases, inflammatory disorders, neurological degeneration, wound healing, infectious diseases and aging, which led to search for foods rich in antioxidants. Various studies on antioxidant properties of honey have been done. The present article is a short review on the antioxidant properties of honey and its role against health disorder.

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Section: Acacetinmentioning

confidence: 75%

Antioxidant Properties of Honey and Its Role in Preventing Health Disorder

Khalil¹,

Sulaiman²,

Boukraa³

2010

TONUTRAJ

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“…Human atrial myocyte preparation Human atrial cells were enzymatically dissociated as described previously [19] . The method was approved by the Ethics Committee of Tongji Medical College, and the patients provided consent.…”

Section: Cell Culturementioning

confidence: 99%

Inhibitory effects of hesperetin on Nav1.5 channels stably expressed in HEK 293 cells and on the voltage-gated cardiac sodium current in human atrial myocytes

Wang

Zhang

et al. 2016

Acta Pharmacol Sin

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Aim: Voltage-gated sodium channels composed of a pore-forming α subunit and auxiliary β subunits are responsible for the upstroke of the action potential in cardiac myocytes. The pore-forming subunit of the cardiac sodium channel Nav1.5, which is encoded by SCN5A, is the main ion channel that conducts the voltage-gated cardiac sodium current (I Na ) in cardiac cells. The current study sought to investigate the inhibitory effects of hesperetin on human cardiac Nav1.5 channels stably expressed in human embryonic kidney 293 (HEK 293) cells and on the voltage-gated cardiac sodium current (I Na ) in human atrial myocytes. Methods: The effects of hesperetin on human cardiac Nav1.5 channels expressed in HEK 293 cells and on cardiac Na + currents in human atrial myocytes were examined through whole-cell patch-clamp techniques. Results: Nav1.5 currents were potently and reversibly suppressed in a concentration-and voltage-dependent manner by hesperetin, which exhibited an IC 50 of 62.99 μmol/L. Hesperetin significantly and negatively shifted the voltage-dependent activation and inactivation curves. Hesperetin also markedly decelerated Nav1.5 current inactivation and slowed the recovery from Nav1.5 channel inactivation. The hesperetin-dependent blockage of Nav1.5 currents was frequency-dependent. Hesperetin also potently and reversibly inhibited Na + current (I Na ) in human atrial myocytes, consistently with its effects on Nav1.5 currents in HEK 293 cells. Conclusion: Hesperetin is a potent inhibitor of I Na in human atrial myocytes and Nav1.5 channels expressed in human embryonic kidney 293 cells. Hesperetin probably functions by blocking the open state and the inactivated state of these channels.

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“…1 The prevalence of AF increases with age, with 5% of patients over 65 years and 10% over 80 years. 1 Nonvalvular AF (NVAF) greatly increases the risk of stroke and the severity of stroke episodes, with 60% of these stroke episodes leading to severe disability or premature death. 2,3 Oral anticoagulation therapy is the standard of care for stroke prevention in AF patients.…”

Section: Introductionmentioning

confidence: 99%

Barriers to Warfarin Use for Stroke Prevention in Patients With Atrial Fibrillation in Hong Kong

Lee

Tam

Yan

et al. 2012

Clinical Cardiology

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Background:Oral anticoagulation medications such as warfarin reduce the risk of stroke in atrial fibrillation (AF) but have been underutilized. This study aimed to investigate physicians' perceptions of stroke prevention management and patients' knowledge of AF and warfarin therapy in Hong Kong (HK).Hypothesis:Both physician and patient's knowledge on warfarin use were the barriers for stroke prevention in patients with atrial fibrillation in Hong Kong.Methods:This prospective survey‐based study was conducted between February 2011 and April 2011 to assess physicians' perceptions of stroke prevention management, patients' knowledge of AF, and patients' knowledge of warfarin therapy. The results were scored and compared with those in foreign countries.Results:Sixty‐two physicians and 114 warfarin users were recruited in the study. The average score of HK physicians in the knowledge of stroke prevention therapy in AF patients was lower than that of Australian (AUS) family physicians (HK 2.48 vs AUS 4.02 out of 7). The mean scores of AF patients in Hong Kong regarding the knowledge of AF were lower than that of United Kingdom (UK) (HK 1.16 vs UK 2.24 out of 4) (P < 0.001) and that of Finland (FIN) (HK 2.77 vs FIN 5.94 out of 8) (P < 0.001), respectively. The mean score of AF patients in Hong Kong regarding the knowledge of warfarin therapy was lower than that of AF patients in the United States (US) (HK 2.39 vs US 3.92).Conclusions:The barriers of warfarin use for AF patients in Hong Kong were related to both physicians and patients. Many Hong Kong physicians did not comply with international recommendations of stroke prevention in AF patients, and AF patients had a low knowledge level about the disease and warfarin therapy.Presented at the International Congress of Cardiology, Hong Kong, Peoples Republic of China, February 24‐26, 2012.This study was supported by the School of Pharmacy, the Chinese University of Hong Kong.The authors have no other funding, financial relationships, or conflicts of interest to disclose.

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Acacetin, a Natural Flavone, Selectively Inhibits Human Atrial Repolarization Potassium Currents and Prevents Atrial Fibrillation in Dogs

Cited by 115 publications

References 51 publications

Antioxidant Properties of Honey and Its Role in Preventing Health Disorder

Antioxidant Properties of Honey and Its Role in Preventing Health Disorder

Inhibitory effects of hesperetin on Nav1.5 channels stably expressed in HEK 293 cells and on the voltage-gated cardiac sodium current in human atrial myocytes

Barriers to Warfarin Use for Stroke Prevention in Patients With Atrial Fibrillation in Hong Kong

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