“…There is evidence that childhood trauma results in sensitization of the hypothalamic-pituitary-adrenal axis leading to hyper-reactive pituitary-adrenal and autonomic responses to stress in adulthood (Anda et al, 2006; Heim & Nemeroff, 2001; Heim et al, 2002; Heim et al, 2000). Behaviorally, there is evidence that children and adult victims of childhood abuse have difficulty regulating affective responses to psychosocial stressors (Cloitre, Stovall-McClough, Zorbas, & Charuvastra, 2008; Muehlenkamp, Kerr, Bradley, & Adams, 2010; Shields & Cicchetti, 1998; Glaser, Van, Portegijs, & Myin-Germeys, 2006). These data suggest that individuals with a history of childhood trauma will have more frequent and intense experiences of negative emotions in response to daily stress and greater difficulty modulating expression of negative affect within interpersonal relationships, than individuals without such histories (Glaser et al, 2006; Cloitre, Koenen, Cohen, & Han, 2002).…”