Abuse liability and behavioral toxicity assessment: Progress report from the behavioral biology laboratories of the Johns Hopkins University School of Medicine.

Jv, Brady; Rr, Griffiths; Rd, Hienz; Ge, Bigelow; Hh, Emurian; Se, Lukas; Na, Ator; Mj, Nellis; Rl, Ray; Gd, Pearlson

doi:10.1037/e472912004-001

Cited by 2 publications

(3 citation statements)

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“…Based on these studies, it is clear that conditions have not yet been found, despite decades of efforts, wherein CH are readily self-administered by laboratory animals. Given the very strong correlation between drugs that produce dependence in humans and those that are voluntarily consumed by laboratory animals (Brady et al, 1984;Griffiths, 1980;Griffiths et al, 1978Griffiths et al, , 1980, this is among the strongest evidence for the non-addictive nature of CH.…”

Section: Results From Preclinical Studies and Reports From Experiencementioning

confidence: 99%

“…While intramuscular ( Goldberg et al, 1976 ), inhalation ( Carroll et al, 1990a ), and oral ( Gomez et al, 2002 ) routes of administation also maintain drug-taking behavior, intravenous drug delivery is the most employed route of administration in self-administration studies, as intravenous delivery causes a rapid onset of action, facilitating learning of the association between the operant response and the psychoactive effects of the drug. Animal self-administration experiments demonstrate a very strong correlation between drugs that produce dependence in humans and those that are voluntarily consumed by laboratory animals ( Brady et al, 1984 ; Griffiths, 1980 ; Griffiths et al, 1978 , 1980 ).…”

Section: Results From Preclinical Studies and Reports From Experiencementioning

confidence: 99%

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The serotonin 5-HT_2Creceptor and the non-addictive nature of classic hallucinogens

Canal

Murnane

2016

J Psychopharmacol

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Classic hallucinogens share pharmacology as serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor agonists. Unique among most other Schedule 1 drugs, they are generally non-addictive and can be effective tools in the treatment of addiction. Mechanisms underlying these attributes are largely unknown. However, many preclinical studies show that 5-HT2C agonists counteract the addictive effects of drugs from several classes, suggesting this pharmacological property of classic hallucinogens may be significant. Drawing from a comprehensive analysis of preclinical behavior, neuroanatomy, and neurochemistry studies, this review builds rationale for this hypothesis, and also proposes a testable, neurobiological framework. 5-HT2C agonists work, in part, by modulating dopamine neuron activity in the ventral tegmental area—nucleus accumbens (NAc) reward pathway. We argue that activation of 5-HT2C receptors on NAc shell, GABAergic, medium spiny neurons inhibits potassium Kv1.x channels, thereby enhancing inhibitory activity via intrinsic mechanisms. Together with experiments that show that addictive drugs, such as cocaine, potentiate Kv1.x channels, thereby suppressing NAc shell GABAergic activity, this hypothesis provides a mechanism by which classic hallucinogen-mediated stimulation of 5-HT2C receptors could thwart addiction. It also provides a potential reason for the non-addictive nature of classic hallucinogens.

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Section: Results From Preclinical Studies and Reports From Experiencementioning

confidence: 99%

Section: Results From Preclinical Studies and Reports From Experiencementioning

confidence: 99%

The serotonin 5-HT_2Creceptor and the non-addictive nature of classic hallucinogens

Canal

Murnane

2016

J Psychopharmacol

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“…When operationalized as timing behavior (i.e. time estimation), time perception is strongly linked to the effects of psychoactive drugs, including drugs of abuse, in humans and animals (Ague, 1974;Brady et al, 1984;Church, 1989;Gelenberg et al, 1989;Leigh and Tong, 1976;Meck and Williams, 1997;Shibata et al, 1995;Tong et al, 1978;Vojtechovsky et al, 1970). For example, several studies have reported that nicotine, a potent sympathomimetic, can alter the ability to estimate periods of time (Carrasco et al, 1998a(Carrasco et al, , 1998bLeigh and Tong, 1976;Tong et al, 1978), although the direction of the effect is uncertain.…”

Section: Introductionmentioning

confidence: 99%

Evidence for a relationship between daily caffeine consumption and accuracy of time estimation

Stine

O’Connor

Yatko

et al. 2002

Human Psychopharmacology

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The present study examined the relationship between regular caffeine consumption and time estimation. Sixty participants (aged 18-57 years, mean 24 years) completed a 47 s time estimation exercise and questionnaires related to daily caffeine consumption and perceptions of time. We hypothesized that the effects of caffeine on time estimation would follow a U-shaped pattern such that individuals who reported moderate amounts of daily caffeine would be more accurate in their perceptions of time than would those who reported high amounts of caffeine intake or no daily caffeine consumption. Timing accuracy was computed by dividing participant-reported time by actual time (47 s). Timing accuracy followed a U-shaped curve such that those respondents who reported 'low' daily caffeine consumption (< or = 135 mg/day, n = 24) were the most accurate in their time estimates (mean= 44.2 s). Individuals who reported no caffeine (mean= 69.3 s; n= 7) or 'high' daily caffeine consumption (mean=56.2 s; >135 mg/day, n = 28) were less accurate in their time estimates [F(2, 56)= 3.34, p< 0.05]. Findings suggest that 'low' daily caffeine consumption may enhance time estimation accuracy above that of 'high' or no daily caffeine consumption.

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Abuse liability and behavioral toxicity assessment: Progress report from the behavioral biology laboratories of the Johns Hopkins University School of Medicine.

Cited by 2 publications

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The serotonin 5-HT_2Creceptor and the non-addictive nature of classic hallucinogens

The serotonin 5-HT_2Creceptor and the non-addictive nature of classic hallucinogens

Evidence for a relationship between daily caffeine consumption and accuracy of time estimation

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Abuse liability and behavioral toxicity assessment: Progress report from the behavioral biology laboratories of the Johns Hopkins University School of Medicine.

Cited by 2 publications

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The serotonin 5-HT2Creceptor and the non-addictive nature of classic hallucinogens

The serotonin 5-HT2Creceptor and the non-addictive nature of classic hallucinogens

Evidence for a relationship between daily caffeine consumption and accuracy of time estimation

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Product

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The serotonin 5-HT_2Creceptor and the non-addictive nature of classic hallucinogens

The serotonin 5-HT_2Creceptor and the non-addictive nature of classic hallucinogens