Abundant neutrophil extracellular traps in thrombus of patient with microscopic polyangiitis

Neutrophil extracellular traps in ischemic stroke thrombi

“…24,25 In stent thrombi, neutrophils were also found to be the most abundant type of leukocytes and as such are regarded as a hallmark of stent thrombus formation. [30][31][32][33][34][35][36] Intraluminal thrombi from abdominal aortic aneurysm patients contain NETs as measured by the presence of extracellular DNA-histone complexes 34 and the presence of citrullinated histones that colocalize with NE. 26,27 Additionally, neutrophils support thrombosis by formation of NETs, 14 created when neutrophils release decondensed DNA fibers into the extracellular space.…”

Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease

“…Recently, Nakazawa et al 31 demonstrated the presence of NETs in a thrombus from a patient with microscopic polyangiitis and DVT. Herein, we showed that peripheral PMNs isolated from patients with AAV during active disease released elevated numbers of NETs that expressed TF.…”

At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases

“…The role of neutrophils as mediators of thrombosis is historically a controversial issue; however, accumulating evidence linking NETs with clot formation and propagation supports the involvement of neutrophils in thrombosis and suggests potential mechanisms for neutrophil-driven thrombogenicity [100]. NETs have been detected within thrombus isolated from patients with ANCA-associated vasculitis [101]. TF, a protein present in endothelial tissue and leukocytes, is the major initiator of coagulation and thrombin formation [102].…”