2002
DOI: 10.1042/bj20020514
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Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation

Abstract: The basic helix-loop-helix (bHLH) proteins are intimately associated with developmental events such as cell differentiation and lineage commitment. The HLH domain in the bHLH motif is responsible for dimerization, whereas the basic region mediates DNA binding. Based on sequence alignment and domain analysis, differentially expressed in chondrocytes/stimulated with retinoic acid/split and hairy-related proteins (DEC/STRA/SHARPs) represent a new class of bHLH proteins. The present study describes the functional … Show more

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Cited by 101 publications
(147 citation statements)
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References 42 publications
(65 reference statements)
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“…Cells that lack the functional tumor suppressor VHL (von Hippel-Lindau) express higher levels of DEC1 (24). Forced expression of DEC1 antagonizes serum deprivation-induced apoptosis and selectively inhibits the activation of procaspases (23). These findings suggest that overexpression of DEC1 provides cells with an unusual survival mechanism and thus is oncogenic.…”
mentioning
confidence: 74%
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“…Cells that lack the functional tumor suppressor VHL (von Hippel-Lindau) express higher levels of DEC1 (24). Forced expression of DEC1 antagonizes serum deprivation-induced apoptosis and selectively inhibits the activation of procaspases (23). These findings suggest that overexpression of DEC1 provides cells with an unusual survival mechanism and thus is oncogenic.…”
mentioning
confidence: 74%
“…Plasmid-A cDNA encoding the full-length DEC1 was isolated by a cDNA-trapping method (23,26). Several DEC1 mutant constructs were prepared by PCR with the full-length DEC1 as the template.…”
Section: Methodsmentioning
confidence: 99%
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“…32,33 It has also various roles in cell proliferation, apoptosis, differentiation, carcinogenesis, cellular metabolism, circadian rhythms, immune regulation and functions as a hypoxia inducible gene as well. [34][35][36][37][38] PLOD2-procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2…”
Section: Hpa028921mentioning
confidence: 99%