Abundance of Siderophages in Sputum

Roy, Senjuti; Ray, Manas Ranjan; Basu, Chandreyi; Lahiri, Pulak; Lahiri, Twisha

doi:10.1159/000328371

Cited by 18 publications

(4 citation statements)

References 12 publications

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“…355,356 In addition, when cell types were compared from residents living in a rural area compared with an urban location, the urban-residing people had elevated alveolar macrophages and siderophages. 357 Similar results were observed in children from urban and rural locations. 358…”

Section: Biomarkerssupporting

confidence: 72%

Noninvasive effects measurements for air pollution human studies: methods, analysis, and implications

Mirowsky

Gordon

2015

J Expo Sci Environ Epidemiol

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Human exposure studies, compared with cell and animal models, are heavily relied upon to study the associations between health effects in humans and air pollutant inhalation. Human studies vary in exposure methodology, with some work conducted in controlled settings, whereas other studies are conducted in ambient environments. Human studies can also vary in the health metrics explored, as there exists a myriad of health effect end points commonly measured. In this review, we compiled mini reviews of the most commonly used noninvasive health effect end points that are suitable for panel studies of air pollution, broken into cardiovascular end points, respiratory end points, and biomarkers of effect from biological specimens. Pertinent information regarding each health end point and the suggested methods for mobile collection in the field are assessed. In addition, the clinical implications for each health end point are summarized, along with the factors identified that can modify each measurement. Finally, the important research findings regarding each health end point and air pollutant exposures were reviewed. It appeared that most of the adverse health effects end points explored were found to positively correlate with pollutant levels, although differences in study design, pollutants measured, and study population were found to influence the magnitude of these effects. Thus, this review is intended to act as a guide for researchers interested in conducting human exposure studies of air pollutants while in the field, although there can be a wider application for using these end points in many epidemiological study designs.

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Section: Biomarkerssupporting

confidence: 72%

Noninvasive effects measurements for air pollution human studies: methods, analysis, and implications

Mirowsky

Gordon

2015

J Expo Sci Environ Epidemiol

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“…The similarity between risk estimates for effects of short-term exposure on daily mortality for India and global estimates is however noteworthy, especially given the differences in concentration ranges, source mixtures, demographics, and underlying disease rates, and supports the idea that the temporary use of international studies to estimate Indian disease burden is a good first order approximation. In addition, a limited number of population studies carried out in India corroborate the broader global evidence for the higher incidence of chronic non-communicable respiratory and cardiovascular diseases in India (Basu et al, 2001; Dutta et al, 2012; Lahiri et al, 2000; Ray et al, 2006; Roy et al, 2001; Roychoudhury et al, 2012).…”

Section: Air Pollution and Epidemiology In Indiamentioning

confidence: 74%

Air pollution health research priorities for India: Perspectives of the Indo-U.S. Communities of Researchers

Gordon

Balakrishnan

Dey

et al. 2018

Environment International

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“…Ferritin inhibits oxidant-mediated cytolysis [67] and reduces lipid peroxidation induced by Fenton-type reactions [68]. The proliferation of ferroproteins (e.g., ferritin) in the lungs is regulated by the siderophages (hemosiderin-containing macrophages) [69][70][71]. Cells exposed to pro-oxidant xenobiotic substances, such as asbestos fibres, induce recruitment of monocytes (e.g., macrophages) and cytoprotective agents (e.g., ferritin) as defence mechanisms (see above).…”

Section: New Insights In the Mechanism Of Formation Of Absmentioning

confidence: 99%

Mineral Fibres and Asbestos Bodies in Human Lung Tissue: A Case Study

et al. 2019

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One of the open questions regarding the asbestos problem is the fate of the mineral fibres in the body once inhaled and deposited in the deep respiratory system. In this context, the present paper reports the results of an electron microscopy study of both mineral fibres and asbestos bodies found in the lung tissue of a patient who died of malignant mesothelioma due to past occupational exposure. In concert with previous in vivo animal studies, our data provide evidence that amphibole asbestos fibres are durable in the lungs, whereas chrysotile fibres are transformed into a silica‐rich product, which can be easily cleared. Amphibole fibres recovered from samples of tissue of the deceased display a high degree of crystallinity but also show a very thin amorphous layer on their surface; 31% of the fibres are coated with asbestos bodies consisting of a mixture of ferroproteins (mainly ferritin). Here, we propose an improved model for the coating process. Formation of a coating on the fibres is a defence mechanism against fibres that are longer than 10 µm and thinner than 0.5 µm, which macrophages cannot engulf. The mature asbestos bodies show signs of degradation, and the iron stored in ferritin may be released and potentially increase oxidative stress in the lung tissue.

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Abundance of Siderophages in Sputum

Cited by 18 publications

References 12 publications

Noninvasive effects measurements for air pollution human studies: methods, analysis, and implications

Noninvasive effects measurements for air pollution human studies: methods, analysis, and implications

Air pollution health research priorities for India: Perspectives of the Indo-U.S. Communities of Researchers

Mineral Fibres and Asbestos Bodies in Human Lung Tissue: A Case Study

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