Background: Intentional stent fracture in vivo induces medial dissection/vessel injury. Spontaneous stent fracture in humans can lead to stent collapse, hemodynamic compromise, and embolization of stent fragments, which could be prevented by pre-stenting. Objectives: To evaluate the short-term and mid-term effects of pre-stenting prior to intentional stent fracture on vessel size and integrity in a piglet model. Methods: Five months after 14 low-profile stents (Cook Formula 418 stents) were implanted in the aorta of four piglets, they were intentionally fractured using ultra-high-pressure balloons with (pre-stent group) or without (single stent group) with another stent placed inside. Results: Compared with the single stent group, the prestent group showed a significantly larger vessel lumen area (109 mm2 (89-141) vs. 57 mm2 (47-73), P = 0.019), less mid-term luminal diameter loss (44% (26-59) vs. 75% (62-85), P = 0.007), lack of strut protrusion, and improved endothelialization (100% (89-100) vs. 73% (56-96), P = 0.022). Vessel wall injury was similar between groups at the time of stent fracture; however, the injury score was significantly improved at mid-term in the pre-stent group compared with the single stent group (P = 0.046). No damage to the external part of the blood vessels or the surrounding soft tissue was noted in either group.
IntroductionStent implantation in younger patients is facilitated by the availability of low-profile stents that are deliverable through small delivery sheaths, although these smaller stents cannot be dilated to match an adult vessel size [1][2][3]. Several in vitro studies demonstrate that small-and medium-size stents can be fractured using ultra-high-pressure balloons [4,5]. Recently, an in vivo model of stent fracture (i.e., "unzipping") confirmed the feasibility of intentional fracture of several different stents in pigs; however, the report did not mention vessel patency after fracture and admitted to significant vessel injury secondary to intentional fracture, with Cook Formula stents associated with a slightly lower vessel injury score than other stents Conclusion: Pre-stenting before intentional stent fracture may provide advantages including larger vessel diameter, maintained vessel patency, more complete endothelialization, and lack of stent strut protrusion.