Abstracts of the 8th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocine Tumor Disease

Jiménez-Fonseca, Paula; Prado, Jose Maria Vieitez de; Hernández, José Alberto Galván; Herrero, G. Crespo; Frunza, Ana Madalina; González, María Aurora Astudillo; Llamas, Pilar Pardo; Manuel, Marta Izquierdo; Restrepo, Eduardo Gutiérrez; Lacave, Ángel J.

doi:10.1159/000328441

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“…In our study, mRNA level of Leptin is more abundant in BH group, similarity a full-sib study [ 11 ]. This negative feedback regulates body weight through inhibition of feed intake, and increasing fatty acid and glucose oxidation[ 38 ]. Leptin also increases glucose use, and this is consistent with the function of the insulin signaling pathway which is enriched with up-regulated genes expressed in adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

Integration of Transcriptome and Whole Genomic Resequencing Data to Identify Key Genes Affecting Swine Fat Deposition

et al. 2015

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Fat deposition is highly correlated with the growth, meat quality, reproductive performance and immunity of pigs. Fatty acid synthesis takes place mainly in the adipose tissue of pigs; therefore, in this study, a high-throughput massively parallel sequencing approach was used to generate adipose tissue transcriptomes from two groups of Songliao black pigs that had opposite backfat thickness phenotypes. The total number of paired-end reads produced for each sample was in the range of 39.29–49.36 millions. Approximately 188 genes were differentially expressed in adipose tissue and were enriched for metabolic processes, such as fatty acid biosynthesis, lipid synthesis, metabolism of fatty acids, etinol, caffeine and arachidonic acid and immunity. Additionally, many genetic variations were detected between the two groups through pooled whole-genome resequencing. Integration of transcriptome and whole-genome resequencing data revealed important genomic variations among the differentially expressed genes for fat deposition, for example, the lipogenic genes. Further studies are required to investigate the roles of candidate genes in fat deposition to improve pig breeding programs.

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Section: Discussionmentioning

confidence: 99%