Abstracts of current literature

Hollander, Franklin; Cornell, Albert; Flood, Charles A.; Friedman, Maurice H.; Hancock, J. Duffy; Johnson, Thomas A.; Jones, N. W.; Karr, J. Kenneth; Lerner, Henry H.; Levitsky, Phillip; Love, Jesshill; Lust, Franz J.; Manville, Ira A.; Meyer, Arthur E.; Necheles, H.; Neuwelt, Frank; Overstreet, Sam; Pessel, J. F.; Sandweiss, David J.; Schindler, Rudolph; Simpson, Virgil E.; Sims, H. J.; Tumen, Henry J.; Turell, Robert; Wilbur, Dwight; Wirts, C. Wilmer; Murphy, Francis; Feldman, Maurice; Jones, Allen; Johnson, Thos A.; Levitsky, Philip

doi:10.1007/bf02998410

Cited by 1 publication

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“…These findings, which are consistent with the previous in vitro observations (2), lead us to conclude that passive diffusion, which is the predominant mechanism of linoleic acid absorption at high concentrations, conceals the coexisting facilitated diffusion that was dominant at lower concentrations. A similar concentration-dependent dual mechanism of transport has been reported for other nutrients such as thiamine (14,15), eyanocobalamine (16), retinol (8), and arachidonic acid (17).…”

Section: Discussionsupporting

confidence: 70%

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Linoleic acid absorption in the unaesthetized rat: Mechanism of transport and influence of luminal factors on absorption

Chow

Hollander

1979

Lipids

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Linoleic acid intestinal absorption was studied in the unanesthetized rat. At low (21-1260 micrometer) intraluminal concentrations, absorption took place by facilitated diffusion; while at high (1.26-2.5 mM) concentrations, simple diffusion was the predominant mechanism of transport. At low concentrations (840 micrometer), the equimolar additions of oleic, linolenic, and arachidonic acids or lecithin inhibited the absorption of linoleic acid. Substitution of potassium for sodium in the buffer solution, substitution of Tween 80 for sodium taurocholate, or decrease in the hydrogen ion concentration all resulted in decreased rate of linoleic acid absorption. Increase in sodium taurocholate concentration, or perfusate flow rate increased linoleic acid's absorption. These experiments demonstrate that linoleic acid is absorbed by a concentration-dependent dual mechanism of transport. The absorption rate is modified by the pH, surfactant type and concentration, the simultaneous presence of other polyunsaturated fatty acids, and the thickness of the unstirred water layer.

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Section: Discussionsupporting

confidence: 70%

“…Infusate samples taken prior to perfusion were used for determination of the initial specific activity of linoleic acid. At the end of perfusion, the rats were sacrificed by an overdose of ether, and the length of the perfused jejunum was measured with standardized methods of stretching and dessication (8).…”

Section: Experimental Methodsmentioning

confidence: 99%

Linoleic acid absorption in the unaesthetized rat: Mechanism of transport and influence of luminal factors on absorption

Chow

Hollander

1979

Lipids

View full text Add to dashboard Cite

show abstract

Abstracts of current literature

Cited by 1 publication

References 2 publications

Linoleic acid absorption in the unaesthetized rat: Mechanism of transport and influence of luminal factors on absorption

Linoleic acid absorption in the unaesthetized rat: Mechanism of transport and influence of luminal factors on absorption

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