Abstract:The TATA binding protein is essential for transcription initiation by all three classes of RNA polymerase. It is a two-domain protein in which the sequence of the carboxy-terminal domain (CTD) is strongly conserved (~80% sequence identity among eukaryotes), while that of the N-terminal domain (NTD) is poorly conserved both in size and in sequence. Yeast NTD contains about 60 residues and is highly charged, while human NTD is about 160 residues in length, is relatively uncharged and in addition contains an unin… Show more
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