Abstract W MP41: Co-prevalence of Intracranial and Aortic Aneurysms: A Retrospective Study

Abstract

Introduction: Intracranial aneurysm (IA), abdominal aortic aneurysms, thoracic aortic aneurysms and dissection share genetic and environmental risks. In a retrospective clinical record review, we characterized a population presenting with aortic aneurysm (AA) and subsequently had intracranial vascular imaging (magnetic resonance (MRA), computerized tomography (CTA), or digital subtraction (DSA) angiography). Method: Using the University of Virginia Clinical Data Repository, we searched for patients with a diagnosis of any AA by ICD-9 codes for 2004-2014. We used 3 search strategies to identify individuals with intracranial vascular imaging: 1) CPT codes for MRA, CTA or DSA, 2) their billing codes, and 3) presence of vascular anatomic terms in radiology reports. We then undertook a chart review to confirm intracranial imaging and identify those with a IA. We readjudicated 10% of cases. Results: We identified 5500 cases of AA and 550 cases with evidence of potential intracranial vascular imaging. We report data on 338 of these 550 cases. The available demographic data of the 5500 AA cases and the subset reported were similar (Table). Of the 338 potential cases reviewed, 163 did not actually have intracranial imaging and we could not verify a diagnosis of in 56 case. A total of 212 remain to be reviewed. Of the 119 cases with a CTA, MRA or DSA performed, 23/119 (19.3%) had an IA identified. The descriptive statistics of the demographics and co-morbidities are presented in the table. Conclusion: We found a co-prevalence of 19.3% for IA in a clinical population presenting with AA and undergoing intracranial vascular imaging. These data, though limited, support a potential shared risk for aneurismal disease in the aorta and the brain and warrant further investigation with prospective screening and investigation of the mechanisms of shared risk.