Abstract:Introduction:
Cardiovascular risk factors including obesity accelerate the rate of ischemic white matter lesions through unknown mechanisms. Disruption of the normal signaling between endothelial cells and oligodendrocytes may drive the acceleration of white matter lesions. Here, we performed gain and loss of function studies of the IL-17/CXCL5 signaling cascade in white matter endothelia and determined the effect on oligodendrocytes.
Methods:
Obesity-i… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.