Abstract TP214: Descriptive Epidemiology of Ischemic Stroke Patients With Atrial Fibrillation: EAST-Af study from South Korea and Japan

Abstract

Introduction: We present a descriptive epidemiology data of ischemic stroke patients with atrial fibrillation from South Korea and Japan. Methods: Based on prospective registries from South Korea (CRCS-K registry) and Japan (SAMURAI-NVAF study), we collected acute ischemic stroke or transient ischemic attack (TIA) patients with documented atrial fibrillation between 2011 and 2014. Data elements, data fields, and their definitions were harmonized to generate a single dataset. A total of 6036 patients were includedin the analysis (4844 from CRCS-K and 1192 from SAMURAI-NVAF). Results: Regarding baseline characteristics, noticeable differences were found in the following variables between South Korea and Japan; mean age at onset (73.7 ± 10.1 vs 77.7 ± 9.9), TIA as an index event (2.3% vs 4.3%), diabetes (28.6% vs 20.1%), dyslipidemia (28.1% vs 32.9%), smoking (28.3% vs 36.9%), antiplatelets before stroke (39.5% vs 24.3%), anticoagulants before stroke (16.9% vs 31.8%), and recanalization treatment (31.6% vs 22.3%). Median [interquartile range] NIHSS score at admission was comparable (9 [3 - 16] vs 8 [2 - 18]). Functional recovery and event outcomes were different between two countries; mRS score 0 - 1 at 3 months (31.9% vs 36.9%), mortality at 3 months(16.8% vs 6.3%) and at 1 year (22.8% vs 15.4%) and recurrent stroke until 1 year (6.2% vs 10.6%). Conclusions: In spite of common ethnic and cultural background, ischemic stroke patients with atrial fibrillation in South Korea and Japan differ in the following points; 1) favorable recovery and event outcomes of Japanese patients in spite of older age at onset, 2) lower pre-morbid anticoagulants in South Korea, and 3) lower rate of acute recanalization treatment in Japan.