Abstract:Background:
Genome-wide association studies (GWAS) identified the histone deacytelase 9 (HDAC9) gene region as the leading risk locus for large artery atherosclerotic stroke.
Hdac9
deficiency was shown to attenuate atheroprogression in
Apoe
-/-
and
Ldlr
-/-
mice, however the mechanisms linking HDAC9 to atherosclerosis remain elusive.
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