Abstract:Hemorrhagic stroke can occur from traumatic or spontaneous causes, is associated with high morbidity and mortality, and represents a worldwide major public health problem. With breakdown of the blood-brain barrier, and entry of toxic blood components and metabolites within the brain, a highly oxidative environment ensues and leads to a toxic neuroinflammatory cascade. A major cause of the debilitation following brain hemorrhage is due to the direct toxicity of blood components, namely hemoglobin (Hb), the most… Show more
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