Abstract:While the TP53 gene is mutated in about half of all human cancer cases, it remains wild type (wt) in the other half, suggesting that its tumor suppressor activities are either abrogated or circumvented in the latter cases. Moreover, while early evidence indicates that p53 can also exert non-cell-autonomous tumor suppressive activities in the tumor stroma, p53 typically remains wt in stromal cells. These observations raise the question of what exactly happens to p53 in tumors where the TP53 gene is not mutated.… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.