Abstract:The presence of tertiary lymphoid structures (TLSs) and a high intratumoral density of B lymphocytes have been associated with improved survival in several tumor types. TLSs are heterogenous organized lymphoid aggregates, their mature form containing a germinal center with follicular B cells juxtaposing CD4+ follicular helper T cells and intricated with CD21+CD23+ follicular dendritic cells. We investigated the impact of TLS on responses to immunotherapy.
By performing a large-scale retrospectiv… Show more
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