Abstract

Yaffe, M. J.; Bunch, P. C.; Desponds, L.; Jong, R. A.; Nishikawa, Robert M.; Tapiovaara, M. J.; Young, K. C.

doi:10.1093/jicru/ndp032

Cited by 2 publications

(2 citation statements)

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“…The resulting excessive production of ROS may lead to oxidative damage to deoxyribonucleic acid (DNA), lipids, and proteins. It has been reported that Cr(VI) compounds may induce injury to brain [26], heart [27], lungs [28], kidneys [29,30], spleen [31], pancreas [32], gastrointestinal system [33], and other vital organs [34] depending on dose level, schemes of treatment, and route of administration [35,36].…”

Section: Discussionmentioning

confidence: 99%

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Oxidative Stress Markers and Histological Analysis in Diverse Organs from Rats Treated with a Hepatotoxic Dose of Cr(VI): Effect of Curcumin

García-Niño

Zatarain-Barrón

Hernández-Pando

et al. 2015

Biol Trace Elem Res

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Hexavalent chromium [Cr(VI)] compounds are extremely toxic and carcinogenic. Despite the vast quantity of reports about Cr(VI) toxicity, the information regarding its effects when it is intraperitoneally (i.p.) administered is still limited. In contrast, it has been shown that curcumin prevents hepatotoxicity induced by a single intraperitoneal injection of 15 mg/kg body weight (b.w.) of potassium dichromate (K2Cr2O7). This study aims to evaluate oxidative stress markers, the activity of antioxidant enzymes, and the potential histological injury in brain, heart, lung, kidney, spleen, pancreas, stomach, and intestine from rats treated with a hepatotoxic dose of K2Cr2O7 (15 mg/kg b.w.), and the effect of curcumin pretreatment. Rats were divided into four groups: control, curcumin, K2Cr2O7, and curcumin+K2Cr2O7. At the end of the treatment, plasma and ascites fluid were collected and target organs were dissected out for biochemical and histological analysis. K2Cr2O7 induced hepatotoxicity but failed to induce in all the other studied organs either oxidative or histological injury, since levels of malondialdehyde (MDA), glutathione (GSH), and the activity of superoxide dismutase (SOD), catalase (CAT), and related GSH enzymes were unchanged. As expected, curcumin was safe. Lack of K2Cr2O7-induced toxicity in those target organs could be due to the following: (1) route of administration, (2) absorption through the portal circulation, (3) lower dose than needed, (4) short time of exposure, or (5) repeated doses are required to produce damage. Thus, the intraperitoneal injection of 15 mg/kg of K2Cr2O7, that is able to induce hepatotoxicity, was unable to induce histological and oxidative damage in other target organs.

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Section: Discussionmentioning

confidence: 99%

“…induced the enlargement of the capsule and depletion of the red pulp cells in the spleen, accompanied by an increase in macrophages. Dey and Roy [31] injected rats i.p. with Cr(VI) as chromium trioxide at a dose of 0.8 mg/100 g b.w.…”

Section: A B C Dmentioning

confidence: 99%

Oxidative Stress Markers and Histological Analysis in Diverse Organs from Rats Treated with a Hepatotoxic Dose of Cr(VI): Effect of Curcumin

García-Niño

Zatarain-Barrón

Hernández-Pando

et al. 2015

Biol Trace Elem Res

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Gestão da inovação em empresas de base tecnológica: um estudo de caso em empresas incubadas

Ocampo

Iacono

Leandro

2019

Innovar

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Este artigo tem como objetivo principal analisar o comportamento das atividades de inovação em empresas de base tecnológica que passaram por um processo de incubação. Para tal, realizou-se uma pesquisa exploratória baseada em um estudo de caso múltiplo aplicado a seis empresas de base tecnológica graduadas de uma incubadora, a partir do modelo de gestão de inovação de três etapas: buscar, selecionar e implementar. A pesquisa destaca o papel que a incubadora tem no acompanhamento das atividades de gestão das Empresas de Base Tecnológica (EBTs) durante a fase de incubação e o comportamento das empresas nas atividades que fazem parte do processo de gestão da inovação. Os resultados mostram aspectos positivos e negativos das atividades do processo de gestão de inovação nas empresas estudadas. O baixo desempenho na aplicação de procedimentos para estudar as oportunidades de mercado e identificar melhorias potenciais nos produtos existentes foi evidenciado através dos índices calculados. Adicionalmente, as auditorias de projetos de inovação e os planos de investimento em pesquisa e desenvolvimento foram identificadas como as ferramentas de gestão menos padronizadas pelas EBTs. Elementos dentro das rotinas de gestão de inovação destacados como positivos foram os joint ventures para a concepção de novos produtos, a troca de know-how e a alavancagem de capacidade tecnológica. Finalmente, as EBTs mostraram um bom desempenho no índice atrelado à implementação de testes e ensaios antes do lançamento de novos produtos e/ou serviços ao mercado.

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Abstract

Cited by 2 publications

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Oxidative Stress Markers and Histological Analysis in Diverse Organs from Rats Treated with a Hepatotoxic Dose of Cr(VI): Effect of Curcumin

Oxidative Stress Markers and Histological Analysis in Diverse Organs from Rats Treated with a Hepatotoxic Dose of Cr(VI): Effect of Curcumin

Gestão da inovação em empresas de base tecnológica: um estudo de caso em empresas incubadas

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