Abstract:Background: The Tumor Proportion Score (TPS) and Combined Positive Score (CPS) scoring algorithms are used in conjunction with PD-L1 IHC 22C3 pharmDx for the immunohistochemical evaluation of PD-L1 in certain human cancer tissues; both algorithms include PD-L1 staining tumor cells (TC) and have been correlated with response to pembrolizumab therapy (KEYTRUDA®) at specific expression levels in specific tumor indications. This study aims to evaluate whether PD-L1 expression on TC could be important in the evalua… Show more
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