“…propose that disruption of the gut barrier by ICI allows translocation of inosine produced by gut bacteria into systemic circulation, which thereby activates T cells via the adenosine A 2A receptor [51] . However, preliminary studies suggest that inosine may facilitate metastasis via decreased cAMP and thereby cell-extracellular matrix adhesion in prostate cancer [52] . Interestingly, another major inosine producer, Bifidobacterium pseudolongum , was significantly increased in responders in both the First Timepoint Cohort ( Fig.…”