Abstract:Purpose: Capecitabine is commonly used as a first-line treatment for gastrointestinal (GI) tract cancers. Common toxicities of capecitabine include diarrhea and hand-foot syndrome (HFS), which frequently lead to dose reduction, interruption, and even discontinuation. While racial and ethnic differences in capecitabine toxicities have been suggested by case reports, they have not been systematically evaluated in diverse ‘real-world’ populations. This study examined differences in capecitabine-related diarrhea, … Show more
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