Abstract:Background: In the U.S., around 252,710 new breast cancer cases will be diagnosed in the year 2017. About 15-20% of these patients will be candidates for treatment with Her-2 directed therapy. The College of American Pathologists (CAP) published initial guidelines for immunohistochemistry (IHC) in 2003 with revisions in 2007 and 2013. 2013 guidelines define 3+(positive) as >10% intense complete membrane staining similar to 2003; >30% complete in 2007. Equivocal 2+ category in 2013 includes incomp… Show more
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