Abstract:Background: Breast cancer cells deficient for BRCA1 are hypersensitive to agents eventually resulting in double-strand DNA breaks, such as platinating agents and poly(ADP-ribose)polymerase (PARP)-inhibitors. Using a BRCA1 array comparative genomic hybridization (aCGH) classifier, we previously identified BRCA1-like tumors with a functional BRCA1-loss, caused by BRCA1-mutation, BRCA1-promoter methylation, or an as yet unidentified mechanism. We observed that these BRCA1- like(CGH) tumors showed an expansive gro… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.