Abstract: P746 PREPROCEDURAL C-REACTIVE PROTEIN PREDICTIVE VALUE IN ANGIOGRAPHIC IN-STENT RESTENOSIS AFTER CORONARY STENT PLACEMENT IN PATIENTS WITH STABLE ANGINA

Khosravi, A; Mehr, Gilda Kiani; Poormoghadas, M; Tavasoli, Ali Akbar

doi:10.1016/s1567-5688(09)70115-1

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…Since interventional cardiologists are being asked to perform PCI on increasing numbers of elderly patients with significant co-morbidities, such as diabetes and/or renal insufficiency, contrast nephropathy is a potentially serious complication of PCI [ 24 , 25 ]. Other risk factors also should be taken into accounts as contributors of PCI complications and adverse outcomes [ 26 - 29 ].…”

Section: Discussionmentioning

confidence: 99%

Markers of kidney function in the elderly in relation to the new CKD-EPI formula for estimation of glomerular filtration rate

Małyszko

Bachórzewska−Gajewska²,

Małyszko³

et al. 2011

aoms

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IntroductionNeutrophil gelatinase-associated lipocalin (NGAL) has been recently proved useful in the quantitation of chronic kidney disease (CKD). The aim of the study was to assess prevalence of CKD according to the Modification of Diet in Renal Disease (MDRD), Cockcroft-Gault, and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulae in 412 patients with normal serum creatinine and markers of kidney function/injury such as NGAL, cystatin C, and kidney injury molecule-1 (KIM-1) in these patients in relation to age (below and over 65 years).Material and methodsWe included in the study 1005 patients with coronary artery disease and normal serum creatinine. However, markers of kidney function/injury were assessed in 412 patients. The NGAL, cystatin C and KIM-1, were assessed using commercially available kits.ResultsPatients over 65 years had significantly lower estimated glomerular filtration rate (eGFR) than their younger counterparts despite identical creatinine. They also had significantly lower haematocrit, despite similar Hb, lower platelet count, higher serum fibrinogen, higher systolic (SBP) and lower diastolic blood pressure, higher serum NGAL and cystatin C, but similar urinary NGAL and KIM-1. Serum NGAL correlated with age, haematocrit, leukocyte, platelet and erythrocyte count, eGFR, creatinine, fasting glucose, HbA1c, fibrinogen, SBP, and diabetes duration. In multiple regression analysis kidney function (eGFR, creatinine clearance or creatinine), cystatin C and SBP were predictors of serum NGAL.ConclusionsIn our study we found a very high prevalence of CKD up to 61% in elderly patients with coronary artery disease and normal serum creatinine. Neutrophil gelatinase-associated lipocalin could be a sensitive marker of kidney function, particularly in elderly patients with another risk factor for kidney damage, i.e. hypertension.

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Section: Discussionmentioning

confidence: 99%

Markers of kidney function in the elderly in relation to the new CKD-EPI formula for estimation of glomerular filtration rate

Małyszko

Bachórzewska−Gajewska²,

Małyszko³

et al. 2011

aoms

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“…Oxidative stress and inflammation are considered risk factors for serious diseases such as heart diseases and cancers (35)(36)(37)(38). Various studies reviewed in this study showed that Ber attenuated DOX-induced nephrotoxicity by reducing total reactive oxygen species (ROS), lipid peroxides, NF-κB p65, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and caspase-3 (39).…”

Section: Discussionmentioning

confidence: 98%

Berberine efficacy against Doxorubicin-induced cardiotoxicity: A systematic review

Khaledifar

Khosravifarsani

Raeisi

2023

J Herbmed Pharmacol

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Cardiotoxicity is one of the main complications of chemotherapy that increases morbidity and mortality in cancerous patients. The present systematic review aimed to investigate the protective effects of berberine (Ber) on doxorubicin (Dox)-induced cardiotoxicity. The study protocol was developed following the PRISMA statement. An extensive search was performed in multiple databases, including Embase, PubMed, Cochrane library, Web of Science, and Scopus. After defining the inclusion/exclusion criteria of the study, 12 records were included. The desired data of the retrieved articles were extracted from the studies and imported into an Excel form and ultimately, the effects, probable outcomes and mechanisms were surveyed. By activating sirtuin 1 (SIRT1), Ber caused reduced oxidative damage and loss of mitochondria integrity in cardiomyocytes. It also regulated autophagy and apoptosis via down-regulating AMP-activated protein kinase (AMPK), nucleotide-binding oligomerization domain, leucine rich repeat, and pyrin domain containing protein (NLRP) activation. Moreover, Ber increased superoxide dismutase (SOD), catalase (CAT), and plasma glutathione peroxidase (GSH-Px) activities, reduced the levels of malondialdehyde (MDA), up-regulated SIRT3, and subsequently reduced oxidative stress in cardiomyocytes and loss of mitochondria integrity, leading to developed apoptosis and regulating the histopathological and electrocardiogram changes in the myocardium. It also ameliorated the DOX-induced calcium ions (Ca2+) and iron overload. Ber reduced oxidant and inflammatory activity, and regulated apoptosis of cardiomyocytes, thus protecting the cells against DOX-induced cardiotoxicity.

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“…Over the last years, several studies have suggested that some factors, e.g. endothelin-1, C-reactive protein (CRP), dimethylarginine, haptoglobin polymorphism, transforming growth factor β (TGF-β), heat shock protein 70 (HSP70), plasma nitric oxide (NO) and vascular endothelial growth factor (VEGF), could be markers of risk for endothelial dysfunction and have an impact on long-term prognosis in patients with CAD [45][46][47][48][49][50][51][52][53][54][55]. Some studies showed that proton pump inhibitor based therapy may have beneficial effects in patients with CAD.…”

Section: Hypertension Update 2011mentioning

confidence: 99%

Lipids, Blood Pressure, Kidney-what was New in 2012?

Banach¹,

Hering²,

Myśliwiec³

et al. 2012

International J. of Pharmacology

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Abstract: P746 PREPROCEDURAL C-REACTIVE PROTEIN PREDICTIVE VALUE IN ANGIOGRAPHIC IN-STENT RESTENOSIS AFTER CORONARY STENT PLACEMENT IN PATIENTS WITH STABLE ANGINA

Cited by 3 publications

References 37 publications

Markers of kidney function in the elderly in relation to the new CKD-EPI formula for estimation of glomerular filtration rate

Markers of kidney function in the elderly in relation to the new CKD-EPI formula for estimation of glomerular filtration rate

Berberine efficacy against Doxorubicin-induced cardiotoxicity: A systematic review

Lipids, Blood Pressure, Kidney-what was New in 2012?

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