Abstract:Background: Sequencing of single-agent chemotherapy (CT) is the current standard of treatment for endocrine-resistant metastatic breast cancer (MBC). However, shrinking benefit for consecutive lines of CT and lack of data from randomized trials may question the real value of advanced lines of treatment. Growth modulation index (GMI), the ratio of progression free survival (PFS) with PFS of previous line, has been reported as a marker of treatment benefit when equal to or above 1.3. This value is similar to the… Show more
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