Abstract P4-04-07: High-throughput barcode screening elucidates the functional characteristics and mutual relevance of PIK3CA and PIK3R1 somatic mutations in Chinese patients with breast cancer
Abstract:Background
Deregulation of the phosphoinositide 3-kinase (PI3K) signaling pathway is essential to malignant cellular processes of breast cancer, including proliferation and drug response. Oncogenic somatic mutations of the PI3K pathway are pervasive in breast cancer. However, identification of impactful mutations and determination of their relevance to major components of this pathway remains difficult. This study was conducted to identify the landscape of somatic mutations in the PI3K pathway i… Show more
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