Abstract:Estrogen Receptor α (ERα), a member of the large superfamily of nuclear receptors, exerts profound effects on gene expression, cellular response programs, and phenotypic properties of estrogen target cells. Because of these broad and important actions, ERα is considered the single most important predictor of breast cancer prognosis and is the target of endocrine therapies. The importance of kinases in cancer biology is well known, as increased kinase activity through phosphorylation, mutations or increased exp… Show more
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