Abstract P226: Longitudinal Work Hour Patterns Associated With Diabetes Risk

Abstract

Introduction: Evidence shows a positive correlation between work hour (WH) duration and incident diabetes (DM). However, little is known about the association between longitudinal WH patterns and the risk of incident DM. Hypothesis: We hypothesized that the greatest risk of DM would be observed in consistently long WH patterns and that age, sex, and ethnicity would modify the relationship between WH patterns and incident DM. Methods: We utilized a representative sample of 15,843 U.S. adults from the Panel Study of Income Dynamics who reported weekly WH for a minimum of five years between 1985-2017 and did not have a history of DM prior to reporting five years of WH data. Latent class linear mixed modeling was used to identify distinct longitudinal WH trajectory patterns. Multivariable logistic regression analyses were then used to examine the association between WH patterns and incident DM, with initial adjustments made for sex, age, ethnicity, education, income-to-needs ratio, and occupation. We also tested for statistical interactions between WH patterns and baseline age, sex, and ethnicity. Results: Over a mean follow-up of 17.5 years, four WH trends were identified: standard, full-time (61.1%), increasing (11.5%), quickly decreasing (11.3%), and gradually decreasing (16.1%). Age (interaction p=0.013), but not ethnicity nor sex, modified the association between WH patterns and incident DM. In age stratified analyses, adults aged 18-29 showed no significant association between WH patterns and DM. In adults aged 30-39, a gradually decreasing WH trend showed lower DM risk compared to those working standard hours (OR=0.59; 95% CI: 0.45 - 0.77). Among those ≥40 years, both quickly decreasing (OR=0.66; 95% CI: 0.50 - 0.87) and gradually decreasing (OR=0.45; 95% CI: 0.34 - 0.60) WH patterns were associated with lower risk of DM compared to those working standard hours. Conclusion: Compared to individuals working standard WH over many years, decreasing WH patterns were associated with a lower risk of incident DM.