2023
DOI: 10.1158/1538-7445.sabcs22-p2-20-02
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Abstract P2-20-02: Enrichment of atypical memory double negative (CD27— IgD—) tumour infiltrating B cells following neoadjuvant chemotherapy for early-stage breast cancer

Abstract: Background: Humoral immune responses have previously been associated with improved outcomes, with B cell infiltrates able to independently predict pathologic complete response to neoadjuvant chemotherapy (NACT). B cells represent a diverse population of cells and the complex interplay between specific B cell subsets in the context of chemotherapy treated breast cancers remains unclear. Here, we investigate the dynamic changes in the B cell immune landscape before and after NACT treatment across different breas… Show more

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“…In a cohort of early-stage breast cancer samples, CD21- CD27- IgD- CXCR5- B cells, suggestive of ABCs, were enriched in the TME. Pre-treatment, these represented about 35% of CD27- IgD- B cells, while expanding to nearly 90% post-chemotherapy ( 38 ). It is tempting to speculate that chemotherapy-induced liberation of damage-associated molecular patterns may signal through TLRs to participate in ABC stimulation and proliferation.…”
Section: Atypical B Cells In Cancermentioning
confidence: 99%
“…In a cohort of early-stage breast cancer samples, CD21- CD27- IgD- CXCR5- B cells, suggestive of ABCs, were enriched in the TME. Pre-treatment, these represented about 35% of CD27- IgD- B cells, while expanding to nearly 90% post-chemotherapy ( 38 ). It is tempting to speculate that chemotherapy-induced liberation of damage-associated molecular patterns may signal through TLRs to participate in ABC stimulation and proliferation.…”
Section: Atypical B Cells In Cancermentioning
confidence: 99%