Abstract:Objectives: The receptor for hyaluronan-mediated motility (RHAMM, intracellular hyaluronan binding protein [IHABP], CD168), whose over-expression in tumors is associated with poor prognosis and early age at diagnosis, localizes to the centrosome, interacts with microtubules, functions in the maintenance of spindle pole stability and is required for centrosomal targeting. A previous study has shown that genetic variation at the HMMR locus (encoding for RHAMM) modifies breast cancer risk among BRCA1 mutation car… Show more
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