Abstract:Molecular profiling has suggested that ER+/HER2+ breast cancer is a distinct entity from ER-/HER2+ breast cancer and confers a worse prognosis in systemically untreated patients. It has recently been reported that genes associated with PI3K/AKT pathway activation predict pathologic complete response in patients receiving trastuzumab-chemotherapy in ER+/HER+ but not in ER-/HER2+ tumors. Past studies have indicated that 30-40% of breast cancers harbor a PI3K mutation, predominantly in exons 9 and 20. We analyzed… Show more
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