Abstract P130: Inflammation-Mediated Modification Of Extracellular Matrix Generates A New Adhesive Substrate For Integrin α
D
β
2
-Dependent Macrophage Retention During Chronic Inflammation
Abstract:The accumulation of pro-inflammatory macrophages in the inflamed vascular wall is a critical step in atherogenesis. The mechanism of macrophage retention within the site of inflammation is not understood yet. High adhesion that prevents macrophage migration is one of the potential mechanisms. We previously showed that integrin α
D
β
2
is upregulated on pro-inflammatory macrophages, promotes macrophage retention, and contributes to atherogenesis. However, we have … Show more
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