Abstract:Apelin and its G protein-coupled receptor (GPCR) APJ, which is most closely related to the angiotensin II (Ang II) type 1 receptor (AT
1
) but Ang II does not bind to APJ, are potent regulators of the cardiovascular system. Although recent studies have suggested that apelin-APJ reverses the function of Ang II-AT
1
, the mechanism remains unclear because the accumulating evidences indicates that apelin-APJ may contribute to both cardioprotection and pathological p… Show more
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