Abstract P1-10-26: Gene expression levels of DTX3, CACNA1G, IL11, ETV4 and TSPAN7 selected by LASSO penalty regression could predict pCR after neoadjuvant chemotherapy in breast cancer tumors
Abstract:Introduction: While pCR has been amply associated with improved treatment outcome in patients treated with NAC and surgery, there are only few studies that explore the molecular determinants of pCR. Given the discrete percentage of patients who achieve pCR after NAC, it is of upmost need to identify biomarkers that can discern between responder and non-responder patients before NAC and therefore determine the best therapeutic approach in advance. Our aim is to find the best combination of variables to predict … Show more
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