Abstract P1-03-07: Investigation of combination treatment an aromatase inhibitor and anti-inflammatory treatment in a model of oestrogen receptor positive breast cancer
Abstract:Background: Previous analysis has revealed that high pre-treatment expression of an inflammatory gene expression signature and lymphocytic infiltration are correlated with poor response to neoadjuvant aromatase inhibitor (AI) treatment1. Upon treatment with AIs, inflammatory gene expression also increases1. These changes are also seen in vitro where an increase in chemokine secretion has been observed upon oestrogen deprivation, suggesting that treatment with anti-oestrogen therapy may modulate the immune resp… Show more
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